Antimicrobial Resistance (AMR) in Animal Commensal Bacteria

Antimicrobial resistance is a significant veterinary medical and public health challenge, marked by a worldwide rise in resistant strains. Resistance in commensal bacteria is particularly risky because commensal organisms can serve as a reservoir for resistance genes, which can be horizontally transferred to pathogens or potentially cause opportunistic animal infections. As a Contract Research Organization (CRO) in the field of veterinary research, BioVenic is dedicated to providing commensal bacterial resistance research services, which assist in resistance optimization, enhancing the understanding of the magnitude, spectrum, and mechanism of resistance in commensal bacterial and the relationship between pathogens and animal hosts.

Fig.1 Antimicrobial Resistance in Animal Commensals and Pathogens.

Antimicrobial Resistance (AMR) Services for Commensal Organisms and Pathogens

BioVenic's portfolio encompasses a broad range of services designed to advance your antimicrobial resistance research, from identification and characterization to complex mechanism studies tailored to commensal bacteria and pathogens.

Microbiology Identification and Characterization

Our identification and characterization services for commensal bacteria and pathogens are at the forefront of microbial research. Using advanced molecular techniques such as 16S rRNA sequencing and whole-genome sequencing (WGS), we precisely identify and discover microbial species and strains. Our comprehensive phenotypic characterization includes assessing growth conditions, metabolic capabilities, and resistance profiles, providing a detailed understanding of the microbial community, gene transfer, and host interactions.

• Veterinary AMR Genotypic Characterization
• Veterinary AMR Gene Discovery
• Veterinary AMR Phenotypic Characterization

Antimicrobial Susceptibility Testing

We offer robust antimicrobial susceptibility testing (AST) to determine the efficacy of various antimicrobial agents against specific microbial isolates, ensuring high accuracy and reproducibility. Utilizing standardized methods such as broth microdilution, disk diffusion, and E-test, as well as advanced molecular-based methods and mass spectrometry methods, our AST services and minimum inhibitory concentration (MIC) analysis are designed to meet specific animal-related research needs and novel antimicrobial alternatives development requirements.

Veterinary AMR PK/PD Services

Our PK/PD services provide a thorough understanding of the relationship between drug concentrations, microbial kill rates, and resistance suppression. We employ in vitro models, animal models, and advanced mathematical modeling to simulate and analyze drug behavior and efficacy. By integrating PK data (absorption, distribution, metabolism, and excretion) with PD parameters (MIC, time-kill curves), we help to predict the optimal dosing regimens needed to achieve therapeutic success while minimizing resistance development. These insights are invaluable for veterinary drug development, helping to refine dosing strategies, enhance efficacy, and reduce the risk of adverse effects. Our PK/PD services support informed decision-making in preclinical stages of antimicrobial development.

Veterinary AMR Mechanism Studies

Our mechanism study services focus on elucidating genetic and biochemical pathways that contribute to commensal microbial resistance. Our services help investigate horizontal gene transfer events, such as conjugation, transformation, and transduction, which play significant roles in the spread of resistance genes among bacteria. Our services are designed to explore mutations in target sites, efflux pump activity, and biofilm formation. By employing cutting-edge techniques like CRISPR-Cas9, transcriptomics, and proteomics, we assist in uncovering the intricate details of resistance mechanisms and host interactions. Our services not only enhance our understanding of AMR but also aid in the identification of novel targets for therapeutic intervention.

Our Advantages

• We provide customized one-stop research solutions to meet commensal bacterial AMR research needs, providing comprehensive insights in probiotics, prebiotics, resistant gene horizontal transfer, host interactions, etc.
• Our team of seasoned scientists brings extensive expertise in microbiology, molecular biology, and pharmacology.
• We employ the latest molecular and microbiological techniques, such as next-generation sequencing and high-throughput screening, ensuring precise and reliable results.
• Our services cater to a variety of animal species, including food animals, companion animals, monogastric animals, ruminants, and aquatic species.

Common Resistant Commensal Bacteria
Staphylococcus pseudintermedius Staphylococcus aureus Enterobacteriaceae

BioVenic is committed to advancing the frontiers of AMR research through meticulous science and innovation. Our services are designed to provide comprehensive insights and research solutions for antimicrobial resistance in both commensal and pathogenic organisms among animals. By partnering with us, you gain access to a team of experts dedicated to supporting your research goals with precision and integrity. We work closely with our clients to design and execute studies that align with research objectives, providing comprehensive pathogen profiling, detailed resistance mechanism analysis, and tailored PK/PD studies. Please don't hesitate to contact us to support your AMR research endeavors with our expertise, cutting-edge technology, and unwavering commitment to excellence.