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Animal circRNA Sequencing
Animal circRNA Sequencing Services
circRNA (circular RNA) is a non-coding RNA in which the 5' and 3' ends are covalently linked to form a closed ring. It is widely found in animals and plays a role in species conservation and tissue specificity. The unique circular structure of circRNA makes it resistant to degradation by RNase, providing it with strong stability within the cell. This enables circRNA to function as a transcription regulator in individual animals for extended periods. BioVenic offers a customized animal circRNA sequencing service, which is a potent scientific research tool utilizing high-throughput sequencing technology and bioinformatics methods to analyze the extensive information present in circRNA in animal samples comprehensively.
Fig.1 circRNA Sequencing in Animal Samples. 1
Animal circRNA Sequencing Services
BioVenic's animal circRNA sequencing (circRNA-seq) solution utilizes next-generation sequencing (NGS) technology to offer global scientific researchers' insights into circRNA-related research, including alternative splicing and pathway regulation. Our one-stop service includes sample processing, library preparation, sequencing, and data processing. We are committed to providing high-quality and efficient technical support to animal scientific research users.
| Category | Origin | Position | |
| Animal circRNA | Exonic circRNA | Exons | Cytosol |
| Intronic circRNA | Introns | Cell Nucleus | |
| Exon-intron circRNA | Exons, Introns | Cell Nucleus |
- Sample Processing and Enrichment
BioVenic has developed a standardized extraction and enrichment process for circRNA, which effectively eliminates ribosomal RNA interference, purifies, and fragments circRNA in samples. We perform multiple steps of rigorous quality checks throughout the extraction process to ensure sample purity, concentration, and integrity.
- Library Construction and Sequencing
BioVenic has extensive experience in constructing animal transcriptome sequencing libraries. We can construct libraries tailored to customers' specific research requirements and guidelines, accurately complete the sequencing comparison process, and thoroughly digitize the information in circRNA.
BioVenic supports database comparative analysis, prediction, gene annotation, genome positioning, and expression analysis for circRNA sample sequencing data. We also provide support for advanced bioinformatics analysis tailored to the specific needs of our customers.
Animal circRNA Sequencing Service Flow Chart
RNA-Seq Analysis Platforms
BioVenic's RNA sequencing (RNA-Seq) platform is tailored for scientific users who need detailed analysis of the influence of RNA on gene expression and cellular function in animal samples. The platform utilizes next-generation sequencing to capture snapshots of animal transcriptomes and identify non-transcriptomic RNA sequences. At the same time, RNA-Seq can achieve quantification and identify differential expression, providing a powerful tool for in-depth exploration of animal physiological health conditions and transcriptome regulation of various common diseases. With this platform you can easily achieve:
RNA-Seq Analysis Workflow
Why Choose Us?
BioVenic's circRNA-seq is conducted using a high-throughput sequencing technology platform. It relies on mainstream databases and analysis software specifically designed for animal circRNA identification.
BioVenic offers tailored circRNA sequencing analysis solutions for different stages, parts, or aspects of animal metabolism, such as growth and development, to ensure comprehensive coverage.
BioVenic's circRNA-seq method involves the mainstream approach of depleting ribosomes and linear RNA fragments to construct a library, enabling precise detection of circRNA in samples. Strict quality control is implemented throughout the project to ensure data quality and stability.
BioVenic has perfected the standardized technical process for animal circRNA sequencing to facilitate the analysis of this unique non-coding RNA type and deliver efficient, high-quality data output to customers. Our team of bioinformatics experts thoroughly analyzes circRNA information across species, enabling customers to delve deeply into the crucial functions of circRNA in transcriptional regulation and to continually search for new RNA targets in animals. Please feel free to contact us to obtain your exclusive circRNA solution.
Reference
- Rahimi, Karim, et al. "Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons." Nature Communications 12.1 (2021): 4825.