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Animal Mesenchymal Stem Cell Solution
Animal mesenchymal stem cells (MSCs) are a type of "seed" adult stem cells that can differentiate, proliferate, and regenerate a variety of tissues and organs. Nowadays, the research and development of animal MSCs in cell therapy, immunotherapy, and tissue repair has become a hot topic. BioVenic offers a comprehensive range of animal MSC solutions. We offer MSC products from multiple species and assist in the isolation, identification, and customization of specific MSCs. We rely on our comprehensive animal cell culture system development platform to design animal MSC culture systems and customize exclusive animal cell culture media and programs. For directional stem cell differentiation, we offer a range of strategies and solutions to control the cell fate of our customers. Our stem cell engineering services utilize state-of-the-art genome modification and three-dimensional culture technology to achieve targeted transformation of your MSCs.
Fig.1 Functions of Animal Mesenchymal Stem Cells.1,2
MSC Isolation and Characterization
BioVenic offers reliable solutions for the isolation, identification, and characterization of MSCs from various animal sources to facilitate research on veterinary cell therapies involving animal MSCs. Our technical experts are familiar with isolation schemes and identification methods for MSCs from various tissue sources. We tailor a service package to meet the specific needs of customer projects. Our goal is to expand the field of in vitro research on animal MSCs by exploring gene transcription, translation, and epigenetic regulation
MSC Culture Development
With its comprehensive animal cell culture system development platform, BioVenic has introduced customized culture system design services for animal MSCs. These services provide scientific researchers with powerful tools for basic and advanced media design, supplement development, and targeted improvement of culture systems for expansion and differentiation. We are committed to meeting the nutritional requirements of animal MSCs for long-term passage or proliferation culture in vitro, as well as their differentiation into bone, cartilage, fat, and other tissues following proliferation culture.
MSC Directed Differentiation
BioVenic has a profound background in animal stem cell research and a thorough understanding of the biological mechanisms and associated factors that influence the differentiation process of cells into internal and external lineages. To meet the diverse needs of scientific researchers in stem cell differentiation, our expert technical team provides customized solutions for the development and implementation of animal MSC differentiation. With advanced stem cell induction technology, rich practical experience, and a mature animal stem cell technology platform, we provide robust support and conduct in-depth research on the differentiation potential of MSCs and how to achieve precise differentiation control.
| Intralineage Differentiation |
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Extralineage Differentiation |
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MSC Engineering
BioVenic focuses on the core technology of scientific research on animal MSCs and provides customized solutions to optimize the tissue engineering of MSCs. Our technical team designs and develops strategies to promote MSC delivery and regulate MSC activity for direct cell modification, cell exocytosis delivery, and three-dimensional culture systems. We standardize the technical parameters involved in functional or therapeutic research projects based on animal MSC development to ensure stability and actively promote efficient research progress.
Animal MSCs in Cell Therapy Applications
| Species | Diseases | Applications |
| Canine | Osteoarthritis | Intra-articular injection of adipose-derived stem cells (ASC) is effective in treating osteoarthritis of the elbow joint in dogs, leading to improvements in pain, lameness, range of motion, and functional ability. |
| Osteochondritis | Intra-articular injection of MSCs significantly reduces pain and improves the functional ability of affected individuals. | |
| Tendonitis and Ligaments Rupture | Autologous adipose MSCs for tendon treatment regulate the inflammatory response post-tendon repair by upregulating prostaglandin reductase 1, M2 macrophages, and proteins essential for tendon formation. This process facilitates optimal healing of scar tissue. | |
| Atopic Dermatitis | The immunomodulatory effects of MSC inhibit the activation of T cells and B cells, the release of anti-inflammatory cytokines, and reduce the proliferation of IL-4 and IFN, thereby decreasing the production of IgE. | |
| Feline | Asthma | MSCs had a positive effect on airway remodeling, reduced airway hyperresponsiveness, and decreased airway eosinophilia. |
| Kidney Disease | Intravenous injection of feline amniotic membrane-derived allogeneic MSCs resulted in a significant improvement in proteinuria, a decrease in serum creatinine levels, and a slight enhancement in urine-specific gravity. | |
| Chronic Gingivostomatitis | MSCs perform immunomodulation by normalizing immune cell subsets, serum protein levels, and cytokine levels. | |
| Inflammatory Bowel Disease | MSCs have immunomodulatory and anti-inflammatory effects. After the intravenous injection of MSCs, the clinical symptoms of sick cats improved or completely disappeared. | |
| Bovine | Chronic Wound Healing | MSCs participate in clearing dead cells and necrotic tissue, promoting angiogenesis, reducing scar tissue formation, aiding in wound contraction, and stimulating epithelial regeneration, thereby promoting wound healing, and reducing local inflammation. |
| Mastitis | MSCs exhibit antimicrobial activity, enhance the expression of anti-inflammatory cytokines, antimicrobial peptides, and angiogenic genes in the milk of animals treated for mastitis, and reduce the expression of pro-inflammatory cytokines. | |
| Reproductive System Diseases | MSCs from various sources are utilized in the treatment of metritis, bilateral ovarian dystrophy, ovarian cysts, and reproductive system lesions. | |
| Diabetes Mellitus | MSCs differentiate into islet-like clusters that express insulin and glucagon. |
Why Choose Us?
Comprehensive Animal MSC Solutions
BioVenic offers one-stop solutions and expert technical support for researchers involved in mesenchymal stem cell research.
Diversified Technology
BioVenic combines cutting-edge technology platforms, such as cell genome editing, three-dimensional cell culture, and cell culture system development, to meet the project requirements related to MSCs.
Strong Research Background
BioVenic has been involved in animal stem cell research for many years. The scientific research services it provides have assisted researchers in their scientific studies.
BioVenic has been engaged in the research and development of animal stem cell products and the provision of stem cell-related technical services for many years. BioVenic has established a large and comprehensive animal MSC bank, developed various cell-related technologies, and standardized processes, and accumulated extensive project experience. Our animal MSC isolation and characterization services, culture development services, induced differentiation services, gene editing services, and stable cell line construction services have addressed the challenges in animal MSC for scientific researchers. We welcome you to contact us to discuss your research needs and receive exclusive animal MSC solutions.
References
- Image retrieved from Figure 1 "Therapeutic mechanisms of action of mesenchymal stromal cells." Ivanovska et al., 2022, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "Functions of Animal Mesenchymal Stem Cells".
- Ivanovska, Ana, et al. "Manufacturing mesenchymal stromal cells for the treatment of osteoarthritis in canine patients: challenges and recommendations." Frontiers in Veterinary Science 9 (2022): 897150.