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Animal RNA Methylation Analysis
Background
BioVenic relies on the widely used Methylated RNA Immunoprecipitation Sequencing Platform (MeRIP-seq), along with other conventional sequencing technologies, to offer comprehensive and highly specialized solutions for researchers investigating the regulatory mechanisms of RNA methylation that impact animal biological processes. Our services are distinguished by various RNA methylation modifications at the post-transcriptional level in animals. We are dedicated to meeting diverse research needs, including the exploration of animal gene expression and its application in physiological or pathological conditions such as animal disease and immunity.
Background
RNA methylation modification is common in the transcription process of mammalian cells and occurs in almost all major types of RNA. With the advancement of next-generation gene sequencing technology and the discovery and research of various RNA methylation patterns, the biological significance, and practical applications of RNA methylation modifications in animal have become more accessible to scientific researchers.
Fig.1 RNA Methylation-Related Processes in Mammals. 1
RNA Methylation Analysis Services
- m5C RNA Related Analysis
BioVenic offers m5C RNA methylation sequencing services, utilizing m5C-specific antibodies to enrich all RNA fragments that undergo m5C modification. This is combined with a next-generation sequencing high-throughput detection platform to accurately locate and quantify m5C modifications on RNA. The m5C customization service allows customers to map m5C methylation modifications of RNA across the entire animal genome, comprehensively analyze the distribution and changes of m5C in the transcriptome and gain a deep understanding of the potential significance of RNA methylation in animal life.
- m6A RNA Related Analysis
m6A RNA methylation is the most prevalent internal modification found in mRNA and plays a crucial role in regulating gene expression, splicing, RNA editing, RNA stability, controlling mRNA lifetime, degradation, and mediating circRNA translation. BioVenic utilizes MeRIP-seq technology to continually enhance detection methods and quantitative accuracy. Combined with a next-generation sequencing high-throughput detection platform, BioVenic precisely identifies and measures these modifications using minimal samples and provides data and analysis reports obtained through rigorous quality control.
| Methylation | Process | Services |
| 5-Methylcytosine (m5C) |
 m5C is prevalent in epigenetic modifications, regulating multiple cellular processes and related to RNA stability, translation efficiency, and gene expression regulation. |
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| N6-Methyladenosine (m6A) |
 m6A is the most abundant RNA modification in eukaryotic cells, affects mRNA stability, protein processing and translation, and is critical for post-transcriptional gene regulation and cellular responses. |
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Why Choose Us?
BioVenic utilizes advanced sequencing and detection analysis platforms to decode the RNA modification code for you, making efficient and comprehensive RNA modification mapping easily achievable.
BioVenic has a comprehensive understanding of the project plan, covering RNA processing, analysis report output, quality control at all stages, and expert guidance. We are dedicated to delivering precise customized services to our users.
BioVenic utilizes multi-optimized MeRIP-seq technology to minimize the sample volume required. We generate high-resolution modification maps of animal RNA to support the scientific research projects of users through enrichment and sequencing.
BioVenic has extensive experience in animal epigenetics-related projects and boasts a fully equipped expert technical team and the scientific research technology platform necessary for project implementation. Propose your animal-related scientific research goals, and our dedicated team will tailor a dependable and effective experimental plan for you. At the same time, a multidisciplinary team of experts converts high-throughput detection data into bioinformatics analysis tailored to your project, encompassing methylation site identification, differential analysis, functional enrichment, and interactive visualization. If you are encountering technical challenges in analyzing animal RNA modifications, please contact us to uncover the biological functions of RNA methylation and facilitate the progress of your research project.
Reference
- Zhou, Yujia, et al. "Principles of RNA methylation and their implications for biology and medicine." Biomedicine & Pharmacotherapy 131 (2020): 110731.