Animal Rumen Microbiota Metabolomics

Ruminants, among herbivores, use rumen fermentation to digest plant cellulose. The physiological structure of the rumen differs from that of the ordinary stomach. Ruminants maintain a symbiotic relationship with rumen microorganisms, and these microorganisms produce enzymes that degrade plant polymers to assist the host in completing the entire digestive process. This relationship is crucial for the animal's overall digestion. Various microbial flora, including bacteria, protozoa, fungi, archaea, and bacteriophages, exist in varying concentrations and continuously produce small molecule metabolites as the animal digests them. BioVenic offers tailored solutions for animal rumen microbial metabolomics, which allows for the study of the physiological mechanisms of ruminant rumen and the interactions between rumen microorganisms and the host. We are committed to using high-throughput omics analysis to allow customers to explore the microbial composition and metabolites of the rumen at different developmental stages and gain a deeper understanding of the nutritional and metabolic activities of ruminants.

Fig.1 Relationship Between Ruminant Microorganisms and Animal Metabolic Diseases. ¹

Animal Rumen Microbiota Metabolomics Services

• Sample Collection and Preparation

The sample collection and processing procedures for animal rumen microorganisms can be customized and adjusted according to the customer's specific scientific research goals. This customization ensures the integrity and authenticity of the collection of small molecule metabolites in the sample, achieving reproducibility and scientific validity in the delivery of the service results.

• Metabolite Detection

BioVenic offers animal sample metabolomics analysis services that utilize a range of biochemical analysis methods and technology platforms. These methods and platforms enable high-throughput detection and identification of metabolites in small sample quantities. At the same time, specialized detection of microbial metabolites is integrated into rumen microbial metabolomics testing services. Finally, we identify and verify the structure of the metabolite and provide a comprehensive and detailed test report.

• Data Acquisition and Bioinformatics Analysis

BioVenic is launching data processing and statistical analysis services for large, complex data sets generated by metabolomic analysis. We utilize our vast expertise in data processing to employ digital modeling and algorithms for the analysis and processing of information acquired through high throughput testing for our scientific clients. The data analysis results were used to examine the correlation between rumen microbial metabolic information and the host's physiological state, life activities, dietary components, nutrients in the rumen, and other host effects.

At the same time, we also offer customized services for Animal Rumen Microbiome Omics to give comprehensive insight in isolating, sequencing, and analysising the bacterial flora in the rumen, as well as conducting genomic studies on specific bacterial groups.

Fig.2 Flow Chart of Animal Non-targeted Metabolomics Analysis Service.

Applications of Animal Rumen Microbiota Metabolomic Analysis

• The presence of symbiotic microbiota in the rumen enables ruminants to utilize lignocellulosic materials and convert non-protein nitrogen into microbial proteins. Given the significant impact of rumen fermentation on ruminant nutrition and metabolism, extensive research efforts have been dedicated to comprehending the microbial metabolomics in the rumen and manipulating it to optimize productivity while minimizing environmental stress.
• Studying the microbial composition and metabolites of the rumen at various developmental stages will also help us understand the dynamic changes in nutrition and metabolism of ruminants as they grow.

Why Choose Us?

BioVenic offers customized statistical analysis services for researchers in the fields of life sciences, animal physiology, and microbiology who are studying animal rumen microbial metabolism samples. BioVenic specializes in providing tailored animal metabolomics solutions based on our customers' specific needs. We deliver accurate and detailed metabolic data, along with comprehensive bioinformatics analysis reports. Please feel free to contact us for more details about our services.

References

1. Xu, Qingbiao, et al. "Gut microbiota and their role in health and metabolic disease of dairy cow." Frontiers in Nutrition 8 (2021): 701511.
2. Newbold, C. J., and E. Ramos-Morales. "Review: Ruminal microbiome and microbial metabolome: Effects of diet and ruminant host." Animal. 14: s78–s86." (2020).