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Aquaculture Vaccine Formulation Development
The prevention and control of aquaculture diseases heavily rely on the use of various antibiotics and chemical substances. However, the prolonged use of chemical inputs not only increases the resistance of pathogens but also harms fish and the aquaculture environment. The development and utilization of aquaculture vaccines represent the safest and most effective means to prevent diseases in aquatic species and maintain the health of aquaculture. BioVenic provides aquaculture vaccine formulation development, covering from administration methods to adjuvant development, while ensuring safety and empowering aquaculture vaccines with superior immunogenicity.
Our Services
Administration Route Optimization
The development and correct use of aquaculture vaccines are crucial for the successful induction of protective immune responses. In aquaculture, three common vaccination methods are used: injection, immersion, and oral immunization. The choice of the optimal immunization method must be based on vaccine characteristics, the type of aquatic species, and other factors. BioVenic provides optimization services for aquaculture vaccine administration routes, taking into account the limitations of each route, to assist you in selecting and optimizing the most suitable method.
| Types | Description | Featured Services |
|---|---|---|
| Injection | Injection provides long-lasting protection to aquatic species. However, it is typically used in larger fish and can potentially cause physical injury. | BioVenic offers a comparative platform for intraperitoneal and subcutaneous injection of aquaculture vaccines, along with adjustments to vaccine concentration. |
| Immersion | Dip vaccination is more widely used and involves immersing small fish for a short time in a highly concentrated vaccine solution. Large numbers of fish can be vaccinated using this method. | BioVenic provides efficacy assessment services, which involve adjusting immersion time, vaccine concentration, and pre-treatment of fish with ultrasound or high-osmolarity solutions to enhance mucosal permeability, thus finding the suitable method. |
| Bath vaccination is used for larger fish and they are exposed for a longer period, usually one to several hours, in a lower concentration of vaccine. | ||
| Oral | Oral administration is a convenient route for antigen delivery and can be used for fish of all sizes. | Due to the influence of digestive enzymes on the vaccine's active components, BioVenic provides encapsulation services to protect vaccine antigens by encapsulating them in carriers, shielding them from adverse stomach conditions in fish. |
Delivery System Development
BioVenic has established a vaccine delivery system research platform to assist you in developing veterinary vaccines. These techniques involve encapsulating antigens in suitable carriers or protective layers to maintain their activity, thereby inducing an effective immune response.
| Delivery Systems | Specific Types | Service Contents |
|---|---|---|
| Biovector | Virus Vector | BioVenic further optimizes vector selection and immunization strategies to enhance the protective efficacy of vector vaccines in aquatic species. We introduce novel probiotic vectors for your consideration. Probiotics, being safe and non-toxic, promote nutrient absorption in the intestines and boost the host's immune system, serving as carriers for live vaccine. |
| Bacterial Vector | ||
| Nanoparticle | Inorganic Nanoparticles | Aquatic species are ultimately consumed by humans, BioVenic offers degradable and safe nanoparticles to deliver veterinary vaccine antigenic components. We offer full synthetic preparation, encapsulation and characterization services, providing antigen-specific immune response. |
| Polymeric Nanoparticles | ||
| Lipid Nanoparticles |
Fig.1 Nanoparticles used in vaccine delivery. 1
Adjuvant Development
For aquatic vaccinology, oil-based adjuvants are widely employed. BioVenic provides adjuvant development services aimed at enhancing the immunogenicity of aquaculture vaccines and extending the duration of vaccine protection. We screen adjuvants, select the ones that best meet your needs, ensure their compatibility with the target antigens, and optimize their delivery methods.
Why Choose Us?
Not limited to companion animals, livestock and poultry, BioVenic also possesses extensive project experience in aquaculture vaccine development.
We offer optimized measures for aquatic species-specific administration route like immersion.
From upstream target antigens to formulation development, you can experience a one-stop service with us.
The realm of aquatic species encompasses a wide range of species and types, with considerable potential for the application and development of vaccines. The aquaculture vaccine formulation development platform established by BioVenic is here to serve those who are dedicated to improving aquaculture vaccine formulations. We are committed to providing comprehensive support in the field of aquaculture vaccine formulation development! Please contact us for more information on our aquaculture vaccine formulation development services.
References
- Harshitha, Mave, et al. "Nanovaccines to Combat Aeromonas hydrophila Infections in Warm-Water Aquaculture: Opportunities and Challenges." Vaccines 11.10 (2023): 1555.
- Radhakrishnan, Akshaya, et al. "Oral vaccination for sustainable disease prevention in aquaculture—An encapsulation approach." Aquaculture International 31.2 (2023): 867-891.
- Du, Yang, et al. "Current status and development prospects of aquatic vaccines." Frontiers in Immunology 13 (2022): 1040336.