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Canine Metabolic Disorder Model Development
As devoted companions to humans, the well-being and nutritional needs of dogs are priorities for pet owners. With a vast variety of dog breeds, each having distinct genetics and dietary requirements, it is crucial to address their specific needs. Additionally, due to the physiological similarities between canines and humans, canine models are increasingly employed in metabolic research studies. At BioVenic, we specialize in creating models of canine metabolic disorders to facilitate canine nutritional research. Our comprehensive Metabolic Disorder Animal Model Development services encompass all aspects of model development, including custom diet formulation and model validation, among others.
Background
Dogs can suffer from a range of nutritional metabolic diseases, including imbalances in carbohydrate, fat, protein, mineral, and vitamin metabolism. These disorders can arise from various causes, including genetic defects, unbalanced or excessive dietary formulations, and specific life stages such as growth spurts, lactation, or old age. Canine models used in nutritional studies are either naturally occurring or induced. These models serve as valuable tools to investigate the mechanisms underlying canine nutritional metabolic diseases, develop innovative nutritional strategies, and provide a foundation for the advancement of therapeutics for related human conditions.
Canine Metabolic Disorder Model Development
- Development of Gene-Induced Canine Metabolic Disorder Models
Certain genetic defects or mutations can render dogs more susceptible to metabolic disorders. For instance, a study by Raffan et al1 identified a mutation in POMC among Labrador retrievers prone to obesity. We provide a comprehensive range of genetic analytical tools to screen for canine metabolic disorders. Through our integrated research platform, we also offer assistance in genetic studies and the development of genetic testing technologies related to canine nutritional metabolic diseases.
Fig. 1 A POMC mutation is common in the obesity-prone Labrador retriever1,2
- Development of Diet-Induced Canine Metabolic Disorder Models
By employing specific feeding methods such as unlimited access to food or customized diets (e.g., high-fat diet), researchers can induce models of canine obesity. Our solutions encompass the development of diet-induced canine nutrient metabolic disorder models. We can propose suitable induction protocols based on your requirements and previous research, conduct testing services for induced feeds, and provide assistance in constructing models that simulate nutrient deficiencies or over-nutrition-induced canine metabolic disorders.
- Evaluation of Biomarkers in Canine Metabolic Disorder Models
Assessing changes in metabolic pathways and biomarkers with potential clinical utility in canine metabolic disorder models is crucial. Not only does it shed light on the nutritional physiology of dogs, but it also provides valuable information for human nutrition. Our services include assays for body fluid biochemical markers, individual metabolites, or metabolomic profiling to evaluate your canine metabolic disorder model.
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Common Metabolic Disorders in Dogs
| Metabolic Disorders | Causes | Indicators |
|---|---|---|
| Obesity | Genetic (breed-related predisposition) and environmental (insufficient exercise, neutering, etc.), energy intake exceeding energy expenditure. |
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| Type 1 diabetes | Insulin-secreting cells in the pancreas are destroyed, resulting in an absolute lack of insulin. |
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| Lipid disorders | Primary (genetic) and secondary (diet, diabetes, endocrine diseases, etc.). |
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| Puerperal hypocalcemia | Loss of calcium into the milk and too little calcium in the diet. |
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| Vitamin D deficiency | Unbalanced diets |
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Applications of Canine Metabolic Disorder Models
- Evaluation of Canine Nutritional Strategies
Canines in specific metabolic states require tailored nutrition. The development of canine nutritional and metabolic disorder models enables customers to conduct experiments on feed formulations, nutritional additives, and feeding methods, among others. This facilitates the identification of suitable nutritional strategies for dogs with metabolic disorders.
- Exploration of Mechanisms in Canine Metabolic Disorders
With the help of our analyzing platform, clients can delve into the mysteries surrounding canine nutritional metabolic disorders. This expands your understanding of the underlying mechanisms involved, ultimately supporting the welfare and health of dogs.
- Prevention and Treatment Development for Canine Metabolic Disorders
By utilizing an untargeted metabolomics approach, the study of nutritional metabolic disorders in both model and normal dogs allows for the identification of differential metabolites from a molecular perspective. This information can serve as a reference for the prevention and management of metabolic disorders.
- Development of Therapies for Humans
As many genetic diseases in dogs have human counterparts, dogs are considered valuable large animal models in human biomedicine. The canine model has played a pivotal role in the early development of various diabetes therapies, including techniques for pancreatic islet transplantation and immunosuppressive protocols.
Why Choose Us?
As enthusiasts of dogs, we possess a profound knowledge of their physiological characteristics and nutritional requirements. We are delighted to offer our assistance in canine nutrition research.
Our extensive range of testing products and services specifically designed for dogs ensures a dependable testing platform that can cater to your needs.
We are committed to comprehending your research requirements for the development of canine nutritional metabolic models and providing prompt responses to meet your expectations.
The requests and privacy of our clients hold great significance to us, and we maintain strict confidentiality for all our research programs.
Our expertise lies in the field of animal nutrition research products and services, with a dedicated focus on delivering comprehensive metabolic disorder model development programs for researchers in canine nutrition. BioVenic's canine metabolic disorder model development service can meet your research needs for model development, optimization and validation. It also has a wide range of applications in canine nutrition, drug and therapy development. If our services resonate with your interests, please don't hesitate to contact us.
References
- Image retrieved from Graphical abstract, Eleanor et al., 2016, used under [CC BY 4.0]. The title was changed to "A POMC mutation is common in the obesity-prone Labrador retriever".
- Raffan, Eleanor et al. "A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs." Cell metabolism vol. 23,5 (2016): 893-900.