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Contract Veterinary Vaccine Manufacturing
Ensuring a reliable supply of pure, safe, potent, and effective vaccines is essential for maintaining animal health. The diversity of new pathogens or outbreaks increases the demand for various vaccine types and manufacturing methods. From a manufacturing perspective, many factors are vital for accelerating the production of veterinary vaccines and achieving performance goals, including process scale-up, upstream production, impurity removal, downstream recovery, and quality control, among others. BioVenic offers contract veterinary vaccine manufacturing services to assist you in scaling up your veterinary vaccine samples from the laboratory stage to commercial production.
Veterinary Vaccine Production Platforms
BioVenic has established various of veterinary vaccine development platforms for different types of vaccine development and production. Our platforms enable high-quality manufacturing of different types of vaccine from lab-scale to large-scale to meet your veterinary vaccine research and development requirements.
| Platforms | Description |
|---|---|
| Live Attenuated Veterinary Vaccine | The infectious potential of attenuated pathogens must be maintained. |
| Recombinant Vectored Veterinary Vaccine | Using attenuated or harmless microorganisms (e.g., adenoviruses) to transport portions of an antigen to stimulate an immune response. |
| Recombinant Protein Subunit Veterinary Vaccine | The manufacture of recombinant protein involves the cellular expression in a variety of heterologous expression systems including mammalian cells, baculovirus-insect cells, eukaryotic cells, and prokaryotic cells. |
| Conjugate Veterinary Vaccine | The covalent attachment of carrier proteins to polysaccharide molecules converts them into T-dependent antigens that efficiently stimulate an immune response. |
| Virus-like Particle Veterinary Vaccine | VLP can be expressed in a variety of heterologous expression systems, followed by in vivo assembly and then purification from cell lysates, either by recovering partially assembled proteins from cell lysates or assembling them into VLP in vitro. |
| DNA Veterinary Vaccine | Plasmid DNA is used as the vaccine itself and also as starting material for mRNA vaccines. Its production is plagued by low productivity in microbial fermentation and difficulties in purification. |
| mRNA Veterinary Vaccine | mRNA can be produced synthetically by in vitro transcription without the removal of cellular or host cell proteins. |
Fig.1 Common development platforms for pathogen vaccines. 1
Our Services
Production Process Optimization
The use of new technologies to simplify veterinary vaccine development and manufacturing has become increasingly important. In the manufacturing of your veterinary vaccines, BioVenic provides production process optimization services, identifying numerous opportunities for optimizing vaccine production within analytical and processing technologies.
BioVenic provides comprehensive antigen production optimization services, aiming at improving the yield and stability of antigens to ensure that the final product elicits a good immune response in the animal.
| Antigen Types | Optimization Measures |
|---|---|
| Virus | High-cell-density systems like bioreactors, achieve high titers through fine-tuning cell substrates, viral parameters, and growth conditions. |
| Recombinant Protein |
Various heterologous expression systems. During the expression of recombinant proteins, continuous monitoring, optimization of culture media, and culture processes are implemented. |
| Plasmid DNA |
Strictly control the reagents and materials used throughout the production process so that they are free of endotoxin. The use of Animal-free media ensures the safety of animal research. |
| mRNA |
Using an efficient and economical co-transcription capping technique. Adjusting the process parameters so that the LNP particle size is as uniform as possible and the mRNA is stably encapsulated in the LNP to form stable nanoparticles. |
- Isolation and Purification
Whether it's a pathogen, subunit antigen, or mRNA, post-production, they all need to be separated from the system and then purified. BioVenic offers various purification methods, and to ensure you achieve the optimal purity for your veterinary vaccine antigens, we provide a combination of purification techniques. We tailor the purification process to the specific characteristics of your product, utilizing different purification technologies at each step of the process.
| Sample size | Charge | Hydrophobicity | Ligand specificity |
Scale-Up Manufacturing
BioVenic specializes in providing preclinical-level veterinary vaccine production services to meet the needs of vaccine research and experiments. Our laboratory-scale services encompass antigen design, optimization, small-scale production, and validation, ensuring high-quality antigens are obtained in the initial experimental stages.
Pilot-scale services further offer scaled-up production, optimization, and validation to cater to broader experimental and research requirements. Ultimately, our large-scale production services ensure consistency and stability in veterinary vaccine production on a larger scale, providing continuous support for preclinical studies.
Fig.2 Considerations for long-term veterinary vaccine supply. (BioVenic Original)
Quality Control
The production of safe and effective veterinary vaccines is crucial for ensuring good public health, and as such, veterinary vaccines should be manufactured under controlled and monitored conditions. In veterinary vaccine manufacturing, many control measures are essential to guarantee the production of high-quality vaccines. BioVenic provides rigorous quality control, with strict oversight in various aspects, including raw materials, production processes, infrastructure/facilities, equipment, and personnel.
Why Choose Us?
- Multiple types of veterinary vaccine antigen production platforms for you to choose from.
- A full range of veterinary vaccine production services.
- Laboratory-scale, and pilot-scale productions are achievable for pre-clinical studies.
- Strict quality control ensures the quality of veterinary vaccines.
To ensure the successful immunization of animal populations using veterinary vaccines, it is essential to be able to produce consistently high-quality vaccines. BioVenic's contract veterinary vaccine manufacturing services provide support at every stage of your veterinary vaccine production process according to your requirements. If you wish to produce laboratory-scale veterinary vaccine samples or scale up the production of samples you have developed in laboratory, please contact us for a seamless experience!
Reference
- Barbosa, Raquel de M., et al. "Production Technologies, Regulatory Parameters, and Quality Control of Vaccine Vectors for Veterinary Use." Technologies 10.5 (2022): 109.