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Feed Enzymes-Lipases

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Development and Optimization Application Study Lipases Development Application Effects Workflow Why Choose Us?

Lipases, which are enzymes soluble in water, break down lipid molecules that are not soluble in water, like triglycerides, phospholipids, and galactolipids. They are found widely in nature, across animals, plants, and microorganisms. Incorporating lipase in animal feed can enhance the digestion and absorption of nutrients, thus boosting the economic advantages of animal farming. BioVenic offers a range of solutions for developing feed enzymes, including the development and refinement of feed lipases, investigating lipase applications in feed, and creating feed lipase products tailored to specific animal needs.

Development and Optimization of Feed Lipases

  • Genetic Investigation of Lipases

By utilizing advanced sequencing technologies, we can identify lipase genes in animals and microbes and conduct thorough analyses. This crucial data guides the transformation of lipases into beneficial feed enzymes.

  • Evaluation of Enzyme Characteristics

Effective animal feed lipases must withstand body temperatures and acidic environments. Through our lipase activity assessment tools, we assess key enzymatic characteristics like optimal temperature, temperature resilience, ideal pH, and pH endurance.

  • Study of Lipases Catalytic Mechanisms

Our array of enzyme assessment resources aids in understanding the molecular structure of lipase proteins, facilitating the study of specific lipase catalytic mechanisms. This structural insight is pivotal for enhancing enzymatic features.

  • Enzyme Modification

By combining molecular structure insights with tools like gene mutation, heterologous expression, and signal peptide optimization, researchers can boost lipase expression levels, thermal and pH stability. This enables the creation of high-quality lipases suited for animal feed applications.

  • Fermentation Optimization

Microbial lipases play a vital role in industrial enzyme production. Variations in fermentation conditions can significantly impact enzyme yield. Our expertise helps in optimizing media composition ratios and culture conditions to enhance microbial lipase yield efficiently and reduce production costs.

Application Study of Lipases in Feed

Our feed analysis technology not only assesses the nutritional content of feed, including crude fat, but also examines various fat components. We provide comprehensive analyses of metabolites crucial for animal lipid metabolism, offering a holistic solution for feed assessment and optimization.

  • In Vitro Simulated Digestion

Lipase plays a pivotal role in in vitro animal digestion models. Our Animal Nutrition and Metabolism In Vitro Model Development service replicates the temperature, pH, and other conditions of the animal digestive system. This simulation aids animal nutrition researchers in assessing how lipase interacts with specific feeds in vitro. It helps uncover the potential of lipase as a valuable feed additive.

  • In Vivo Animal Studies

Given the diversity of lipases and animal species, conducting in vivo animal studies is essential to gauge the impact of specific lipases. We provide a diverse array of animal in vivo models to assist researchers in studying the effects of distinct sources, dosages, and forms of lipase supplementation in animals. Through our Animal Nutrition and Metabolism Analysis platform and Omics Solution in Animal Nutrition and Metabolism, researchers can delve into animal biochemical changes pertinent to their research focus.

Feed Lipases Development

Lipase typically serves as a component of enzymatic complexes when utilized in animals. For instance, when combined with an emulsifier, lipase can enhance lipid digestibility, consequently boosting energy utilization from this nutrient source. Our solutions delve into the practical application of feed lipase additive products in vivo and in vitro, shedding light on the effects of lipase alone or when paired with other additives. This aids animal nutrition researchers in formulating animal-specific feed lipase products effectively.

Application Effects of Lipases in Animal Feed

The incorporation of lipase into animal diets has demonstrated improvements in digestibility, growth performance, and product quality. However, the efficacy of lipase varies depending on the animal species and the supplementation approach. The table below illustrates the application effects of some lipases in animals.

Table. 1 Application effects of some lipases in animals

Animals Lipases Effects
Pigs Microbial lipase
  • Enhanced ileal and faecal digestibility of minor fatty acids.
  • Improved apparent ileal digestibility of dry matter (DM), energy, as well as apparent faecal digestibility of DM, organic matter, crude protein, ash, and energy.
Microbial lipase
  • Increased nutrient digestibility in post-weaning pigs during days 0 to 14.
  • Beneficial effects on lipase activity in the duodenum and ileum, as well as protease activity in the duodenum and jejunum.
  • Reduced levels of serum LDL-C, TG, and fecal NH3 in weaning pigs.
Recombinant porcine lipase expressed by Pichia pastoris
  • Potential improvement in fat digestibility and growth performance in post-weaning piglets.
Chickens Commercial lipase
  • Performance enhancement observed in broilers with diets containing reduced energy when lipase and an emulsifier were included, although no improvement in lipid utilization was noted.
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  • Benefits seen in broilers with the supplementation of soy lecithin alone or in combination with lipase through feed.
  • Enhancements in bird performance, carcass traits, improved oxidative stability, prolonged shelf life of meat during refrigerated storage, and increased profitability reported.
Fish Thermomyces lipase expressed in Aspergillus oryzae
  • Influence on the mono-unsaturated fatty acid profiles of rainbow trout fillets.
Commercial lipase
  • Enhancement of intestinal mucosal immunity and antioxidant capacity in fish.
  • Regulation of mRNA expressions of TJ proteins.
  • Regulation of NF-κB, TOR, Nrf2, MLCK in young grass carp.
Dogs Porcine and bacterial lipases
  • Dose-dependent increase in fat absorption observed with both porcine and bacterial lipases in dogs.

Animal Feed Lipases Development Workflow

Fig. 1 Animal feed lipases development workflow (BioVenic Original)

Why Choose Us?

We prioritize understanding our customers' needs by engaging in active and efficient communication. This approach helps us provide tailored and satisfactory solutions that meet their research requirements effectively.

With a strong focus on animal nutrition research, we offer a diverse range of in vivo and in vitro animal research platforms. Our expertise makes us a valuable partner for any animal nutrition study.

Our technology platform is equipped with a variety of testing technologies and research tools to assess application effects. This integration enables us to generate robust results backed by an abundance of data.

In the realm of animal nutrition, the utilization of lipase in feed presents a significant and valuable research avenue. Leveraging our lipase development and production optimization platform, lipase animal application effect research platform, and lipase feed additive product development platform, BioVenic delivers professional and innovative solutions to our customers. If you are interested in exploring our feed lipase development solutions, please contact us. We eagerly anticipate engaging in detailed discussions with you to enhance your animal nutrition endeavors.

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