Feed Fumonisins Solution

Fumonisins are commonly present in corn and corn-derived products, posing a threat to animal health due to their detrimental effects such as diminishing immune response, causing liver and kidney damage, decreasing weight, and raising mortality rates. BioVenic offers advanced solutions for swiftly and precisely identifying fumonisins in animal feed. Our expertise extends to aiding animal nutrition researchers in formulating additives or employing biological methods to lower the risks associated with fumonisins in animal diets, promoting overall well-being.

Fig. 1 Chemical structures of fumonisins B1, B2, B3, and B4^1,2

Origin and Types of Fumonisins

Fumonisins are chiefly produced by Fusarium verticillioides (previously known as F. moniliforme), F. proliferatum, F. oxysporum, F. globosum, various other Fusarium species, and Alternaria alternata f. sp. lycopersici. The most prevalent form is FB1, while related metabolites like fumonisin B2 (FB2) and fumonisin B3 (FB3) are typically found in lower quantities. Additionally, the A, C, and P series encompass other recognized fumonisin analogues.

Fumonisin Hazards in Animals

Numerous animal ailments and cancerous conditions, such as leukoencephalomalacia (ELEM), porcine pulmonary edema (PPE), liver toxicity, hepatocarcinomas, kidney damage, and immunosuppression, are commonly linked to fumonisins. Among the fumonisin variants, FB1 stands out as the primary form and principal toxin. The provided table illustrates the varying impacts of fumonisins on distinct animal species.

Table. 1 Impact of fumonisins on animals

Feed Fumonisins Solutions

Our feed fumonisin solutions facilitate fumonisin analysis, aiding in the development of feed additives and biological processes to mitigate the harmful impacts of fumonisins in animal feed. Additionally, our services encompass efficacy studies and action mode evaluations utilizing diverse animal models.

• Fumonisin Analysis Solutions

Our Animal Feed Mycotoxin Analysis services offer feed fumonisin detection services for various sample types and applications. Commonly employed detection methods include enzyme-linked immunosorbent assay (ELISA), lateral flow rapid assay, and high-performance liquid chromatography (HPLC) with fluorescence detection. These assays effectively identify fumonisin contamination in feeds and support researchers in devising strategies for fumonisin detoxification.

• Feed Additive Development for Fumonisins

To counteract the negative impacts of fumonisins in animal feed, studies have investigated the effects of different feed additives on animal health in fumonisin-exposed animals. Our solution for Feed Additive Development for Fumonisins assesses the efficacy of various types of feed additives and aids in the formulation of highly potent additives to alleviate the harmful effects of fumonisins in animals. Some additives that show promise in reducing fumonisin-related adverse effects include:

• Fumonisin esterase,
• Bentonite and enzymatically hydrolyzed yeast,
• Nanosilicate clay platelets,
• Boron-fructose.

• Development of Biological Detoxification for Fumonisins in Animal Feed

Biological detoxification methods, such as fermentation and enzymatic processes, provide cost-effective and efficient ways to detoxify fumonisins in animal feed. By examining how microorganisms and enzymes interact with fumonisin-contaminated feed, we assist in identifying and cultivating strains and enzymes that can mitigate the detrimental impacts of fumonisins in animal feed. Some of the beneficial biological detoxifying microorganisms and enzymes include:

• Microorganisms:
  Lactobacillus plantarum MYS6
  L. rhamnosus strain GG
  L. paracasei BEJ01
  L. pentosus X8
  Pseudomonas sp.
• Enzymes:
  Carboxylesterase FumD
  Peroxidase

• Animal Study Solutions for Fumonisins

Through in vitro digestion models, the bioaccessibility of fumonisins in different feed varieties can be assessed. In vivo animal models can then be utilized to explore potential methods for detoxifying animal feed contaminated with fumonisins. At BioVenic, we offer both in vitro and in vivo animal models, as well as animal nutrition and metabolism analysis and omics solutions in animal nutrition and metabolism, facilitating the development of feed fumonisin solutions tailored to different animal species..

Service Workflow of Feed Fumonisins Solution

Why Choose Us?

The global prevalence of the mycotoxin fumonisins in maize products has emerged as a significant concern. Fumonisins pose health risks to both humans and animals alike. BioVenic's feed fumonisins solutions offer precise and swift detection methods, aiding in the development of efficient detoxification feed additives and biological processes for animals. If you are interested in accessing our feed fumonisins solutions, kindly contact us with your research requirements. We are committed to providing tailored services that align with your specific needs.

References

1. Image retrieved from Figure 3 "Chemical structures of fumonisins B1, B2, B3, and B4." Kostić et al., 2019, used under [CC BY 4.0]. Without modification.
2. Kostić, Aleksandar Ž., et al. "Mycotoxins and mycotoxin producing fungi in pollen." Toxins 11.2 (2019): 64.