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Inactivated Veterinary Vaccine Development
Similar to live attenuated veterinary vaccines, inactivated veterinary vaccines are also conventional immunization tools that hold significant significance in the realm of infectious disease management. They are physically or chemically treated to denature the proteins or damage the nucleic acids in the pathogen so that they are inactivated and unable to replicate in the host, but they remain partially intact so that they can be recognized and trigger an adaptive immune response. Such vaccines are more stable and safer than live vaccines because dead microorganisms are unable to mutate back to their pathogenic state. BioVenic offers one-stop services for inactivated vaccine research and development.
Types of Pathogens Suitable for Inactivated Veterinary Vaccine Development
Inactivated veterinary vaccines offer versatility in combating a wide array of pathogens, extending beyond prevalent viruses to encompass bacteria, parasites, and more. BioVenic's comprehensive platform empowers researchers in the creation of inactivated vaccines.
| Pathogen Types | Examples |
|---|---|
| Virus | Duck Tembusu virus, Avian orthoavulavirus 1, Rabies lyssavirus, influenza A virus. |
| Bacteria | Pasteurella multocida, Bordetella pertussis, Erysipelothrix rhusiopathiae. |
| Parasite | Neospora caninum. |
| Protozoa and Rickettsia | Leishmania. |
Our Services
Inactivation
Inactivated vaccines are made by inactivating intact pathogens, losing virulence but maintaining immunogenicity. As the cornerstone of development, there are many ways to achieve pathogen inactivation. BioVenic offers a wide range of inactivators and inactivation methods for your research and development use to improve the efficiency of vaccine preparation.
Chemical Methods
formaldehyde, ethylene oxide, ethyleneimine, acetylethyleneimine, β-propiolactone.
Physical Methods
γ-irradiation, UV irradiation, gamma-radiation, electron beam-irradiation.
Fig.1 How to inactivate vaccines? (BioVenic Original)
Adjuvant Development
Inactivated veterinary vaccines are usually unable to directly activate an adequate immune response, and in particular, they are unable to elicit a strong cellular immune response. In order to improve immunogenicity, BioVenic uses appropriate adjuvants during vaccine formulation development. Adjuvants are substances to stimulate and enhance the strength and persistence of the immune response, and these compounds enhance the stability, visibility and immune-inducing ability of the immunogen in the host. BioVenic provides adjuvant development and subsequent safety and immunogenicity assessment services to improve the immune response and immunoprotection of inactivated veterinary vaccines.
Vaccination Optimization
The immunogenicity of inactivated veterinary vaccines is relatively low. Correct selection and optimization of vaccination methods can significantly improve the immunity effect of the vaccine. BioVenic assist customers to comprehensively consider the physiological characteristics of animals, response mechanisms of immune system and characteristics of vaccine components when choosing and optimizing the vaccination method, which activate the immune system to the maximum extent and enhance the immune response of animals, so as to achieve a more effective immune protection effect.
Vaccine Safety and Efficacy Development
Inactivated veterinary vaccines have a high safety profile due to the inactivated state of pathogens, but still require adjuvant addition to enhance immunogenicity, the safety implications of which are yet to be evaluated. BioVenic offers scientific safety and efficacy assessment programs, both in vitro and in vivo, to support the further development of your vaccine candidates.
- In Vitro Assays for Inactivated Veterinary Vaccine Development
- In Vivo Assays for Inactivated Veterinary Vaccine Development
BioVenic has in-depth expertise and state-of-the-art facilities to provide assured inactivation service for your inactivated veterinary vaccines. We focus on providing veterinary vaccine safety and immunogenicity assessment. Even with relatively low immunogenicity due to inactivation of pathogens, we provide formulation optimization services to enhance the immunogenicity of the vaccine through the selection and development of appropriate adjuvants and inoculation methods. Trust our dedication to excellence to navigate the complexities of inactivated veterinary vaccine development. Contact us now, embark on a journey of innovation and success on inactivated vaccine research and development for livestock, poultry, companion animals, aquaculture species and more.