Mouse Anti-Canine Nucleoside Triphosphate Phosphohydrolase 1 (NT5DC1) Monoclonal Antibody

Canine nucleoside triphosphate phosphohydrolase 1 (NTPDase 1) is an ecto-nucleotidase that plays a crucial role in modulating extracellular nucleotide levels, which are critical for various cellular responses via purinergic receptor signaling. This enzyme is responsible for hydrolyzing tri- and/or di-phosphate nucleotides, such as ATP and ADP, to their respective monophosphates. NTPDase 1 is particularly important in immune modulation, as it can influence the host's immune response by affecting the levels of immune-modulatory molecules like ATP. It is also implicated in the evasion mechanisms of parasites from the host's immune defense, suggesting its role in infectious diseases like leishmaniasis in dogs. The enzyme's activity and regulation are essential for processes such as hemostasis, vascular contraction, pain perception, and inflammation, making it a significant target for understanding and potentially treating a range of canine health issues, including thrombotic diseases and immune-mediated conditions.