Mouse Anti-Canine OTU Domain Containing 2 (OTUB2) Monoclonal Antibody

Canine OTU domain containing 2 (OTUB2) is a member of the OTU (ovarian tumor) family of deubiquitinating enzymes, which are crucial for regulating protein homeostasis by reversing ubiquitination. This enzyme plays a significant role in various cellular processes, including cell development and the pathogenesis of diseases such as cancer. OTUB2 is known to mediate the deubiquitination of key proteins in different cell signaling pathways, impacting human health and disease. It has been implicated in the regulation of the NF-κB pathway, where it can influence the polyubiquitination status of NEMO, a key component of the IKK complex, thereby affecting the activation of NF-κB. Additionally, OTUB2 has been shown to interact with and deubiquitinate proteins in the Hippo pathway, impacting the activity of YAP/TAZ and downstream gene expression. Its role in DNA damage repair and immunology further underscores its importance in maintaining physiological functions and its potential involvement in disease pathogenesis.