Mouse Anti-Porcine Fatty Acid Amide Hydrolase (FAAH) Monoclonal Antibody

Porcine fatty acid amide hydrolase (FAAH) is a serine hydrolase enzyme that plays a pivotal role in the degradation of endocannabinoids, such as anandamide and 2-arachidonoylglycerol (2-AG), in the central nervous system (CNS) and peripheral tissues. This integral membrane enzyme is responsible for terminating the signaling of a class of bioactive lipids known as fatty acid amides (FAAs), which includes anandamide, oleamide, and other N-acylethanolamines (NAEs). In pigs, FAAH is involved in a variety of physiological processes, including pain perception, inflammation, neurodegeneration, sleep regulation, and dietary intake. The enzyme's activity is significant for maintaining homeostasis of the endocannabinoid system, which is involved in modulating various disease conditions. FAAH's unique position in modulating the function of diverse endocannabinoids has attracted considerable attention as a therapeutic target for conditions such as pain, inflammation, neurodegeneration, depression, anxiety, and others.