Mouse Anti-Porcine GLI Family Zinc Finger 1 (GLI1) Monoclonal Antibody

Porcine GLI family zinc finger 1 (pGLI1) is a transcription factor that is part of the GLI family, which is central to the Hedgehog signaling pathway-a critical developmental signaling system in vertebrates, including pigs. pGLI1 is characterized by its zinc finger domains that enable it to bind to DNA and regulate the expression of target genes. It plays a pivotal role in various biological processes, such as cell proliferation, differentiation, and tissue patterning. The Hedgehog pathway, when dysregulated, can lead to developmental abnormalities and is implicated in the pathogenesis of various cancers. pGLI1, as a transcriptional effector of this pathway, is responsible for mediating the downstream effects of Hedgehog signaling. Its activity is tightly controlled through a series of regulatory mechanisms, including protein processing and subcellular localization.