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Mouse Anti-Porcine Hexokinase 3 (HK3) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for hexokinase 3. It is affinity purified by protein A. It can be applied to WB, IHC, IF/ICC, FC and ELISA assays of hexokinase 3.
Specifications
Target Information
Porcine hexokinase 3 (pHK3) is a key enzyme involved in the initial step of glucose metabolism, catalyzing the phosphorylation of glucose to glucose-6-phosphate. This reaction is the first and often rate-limiting step in glycolysis, the metabolic pathway that breaks down glucose to produce energy in the form of ATP. pHK3 is particularly important in tissues with high metabolic activity, such as the brain and pancreatic islets, where it plays a crucial role in glucose sensing and the regulation of insulin secretion. The enzyme's activity is regulated by various mechanisms, including feedback inhibition and allosteric modulation, ensuring that glucose metabolism is finely tuned to the cell's energy needs.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Wyatt, Eugene, et al. "Regulation and cytoprotective role of hexokinase III." Plos one 5.11 (2010): e13823.