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Rabbit Anti-Canine Apolipoprotein E (APOE) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for canine apolipoprotein E. It is affinity purified by protein A. It can be applied to WB, IHC and IF/ICC assays of canine apolipoprotein E.
Specifications
Target Information
Canine apolipoprotein E (APOE) is a crucial protein involved in lipid metabolism and transport in dogs. It plays a significant role in cholesterol homeostasis and cardiovascular health. APOE is associated with triglyceride-rich lipoproteins and mediates their clearance after lipolysis in the circulation. It is also synthesized in macrophages, contributing to reverse cholesterol transport to the liver. In the nervous system, APOE distributes lipids among cells, and its variants can influence the risk of neurological diseases, including Alzheimer's. Genetic variations in the APOE gene can impact susceptibility to certain diseases, making it a valuable biomarker for investigating genetic predispositions and potential therapeutic interventions in dogs.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Hui, D. Y., et al. "Isolation and characterization of the apolipoprotein E receptor from canine and human liver." Journal of Biological Chemistry 261.9 (1986): 4256-4267.