Rabbit Anti-Paired Box Gene 6 (PAX6) Polyclonal Antibody

Paired box gene 6 (PAX6) is a crucial transcription factor that plays a multifaceted role in embryonic development, particularly in the morphogenesis of the central nervous system and the formation of eyes. This gene encodes a protein with a characteristic paired box DNA-binding domain, which is essential for the regulation of downstream genes involved in cell fate determination and tissue differentiation. PAX6 is highly conserved across species, underscoring its fundamental importance in development. Mutations in the PAX6 gene are associated with a range of ocular disorders, including aniridia, a congenital condition characterized by the absence of the iris. Additionally, PAX6's influence extends to the development of the pancreas, where it contributes to the formation of insulin-producing beta cells. Targeting PAX6 for therapeutic purposes is an area of interest in regenerative medicine and the treatment of related developmental disorders.