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Veterinary Antigen Labeling
Antigens for veterinary vaccine research and development use can be labeled by binding them with easily detectable or recognizable markers. BioVenic is committed to offering antigen labeling services catering to your diverse needs. Our established antigen labeling platform enables target antigens to be labeled with enzymes, biotin, isotopes, and fluorescence, etc., which makes antigens are more readily detectable, quantifiable, and visualizable during the process of developing veterinary vaccines.
Fig.1 Different protein labeling methods 1
Our Services
Enzyme Labeling
BioVenic provides common enzymes like Horseradish Peroxidase (HRP) and Alkaline Phosphatase (AP) for enzyme labeling experiments, such as Enzyme-Linked Immunosorbent Assay (ELISA).
Biotin Labeling
Biotin is a useful label for detecting, purifying and immobilizing proteins, peptides, and other biomolecules. Its high specificity and stability when binding with avidin/streptavidin make it ideal for various detection and immobilization applications. Biotin is smaller than enzyme labels and thus has minimal interference with protein function.
| Chemical Labeling | Chemical labeling involves attaching biotin molecules to free amino groups at the N-terminus and internal lysine side chains of a protein. This method can lead to multiple biotin molecules being attached to a single protein molecule. |
| Avi-tag Labeling | The Avi-tag is a short peptide tag consisting of 15 amino acid residues that can be biotinylated in vivo and in vitro. It allows the site-specific biotinylation of a protein, which has a relatively minimal impact on the protein's spatial structure. |
Isotope Labeling
Isotope labeling involves replacing essential amino acids in cell culture media with naturally occurring isotopes (light) or stable isotopes (heavy). This allows newly synthesized proteins to be labeled during cell growth by incorporating amino acids with different isotopes. BioVenic's antigen expression platform, combined with its cell culture platform, offers protein isotope labeling services using a variety of elemental isotopes.
Fluorescent Labeling
Conjugating fluorescent dyes to proteins and other biomolecules is a common method for studying antigen structures. Fluorescently labeled target molecules can be used for in vivo tracking and cell sorting. BioVenic provides a range of fluorescent proteins covering various spectral regions, including green, blue, and red. Additionally, it offers protein quantum dot labeling services.
Protein and Peptide Cross-Linking
Cross-linking is a technique for covalently joining two or more biomolecules to create complexes with enhanced physical properties or biological functions. The ability to modify protein or nucleic acid structures is valuable and widely used to study molecular interactions and construct new structures.
| Chemical Cross-Linking | Cross-linkers are widely used for nucleic acid modification, and the same principles apply to protein modification and labeling. The company offers various types of cross-linkers to meet your cross-linking needs for various functional groups. |
| Enzyme Cross-Linking | Enzyme cross-linking strategies not only provide site-specific reactions but also preserve the structural integrity of the protein to a great extent. |
Why Choose Us?
Company offers a variety of antigen markers and labeling services for veterinary vaccine development.
High success rate in antigen labeling.
Provide one-stop services covering upstream and downstream processes, including antigen expression, antigen labeling, and antigen purification supporting veterinary vaccine development.
Ensure batch-to-batch consistency through stringent quality control.
Antigen labeling is widely used in the field of veterinary vaccine development, involving the conjugation of proteins, peptides, nucleic acid molecules, etc., with specific markers for subsequent antigen detection or the study of their interaction with antibodies. To facilitate the smooth progress of your veterinary vaccine development, BioVenic offers antigen labeling services, providing a range of labeling methods and markers to meet your diverse research and development requirements. If you're interested, please contact us and contribute to the advancement of animal health!
Reference
- Moghaddam-Taaheri, Parisa, and Amy J. Karlsson. "Protein labeling in live cells for immunological applications." Bioconjugate Chemistry 29.3 (2018): 680-685.