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Veterinary IL-4 Therapeutic Antibody Development
Background of IL-4
In allergic diseases such as asthma and atopic dermatitis, elevated levels of IL-4 are often linked to the progression and pathological mechanisms of these conditions. Developing antibodies targeting IL-4 or its receptor may effectively inhibit IL-4-mediated immune responses, and improve disease conditions. BioVenic offers veterinary IL-4 therapeutic antibody development services, covering the complete process to facilitate the efficient development of veterinary IL-4 therapeutic antibodies.
Background of IL-4
| Full Name | Interleukin 4 |
|---|---|
| Aliases | BCGF1, BCGF-1, BSF1, BSF-1, IL4. |
| Target Profile | IL-4, primarily produced by activated T cells, mast cells, eosinophils, and basophils, plays a diverse role in the immune system. It regulates the immune functions of B cells, T cells, mast cells, macrophages, and hematopoietic cells, including promoting the differentiation and growth of B cells, enhancing antibody production, modulating macrophage activity, and influencing T cell differentiation and function. |
MoA of IL-4
IL-4 exerts its effects through binding to its receptor. In the signaling cascade, different receptor dimers activate JAK or Tyk2, initiating downstream signaling pathways. Activation of these kinases further stimulates pathways such as STAT6, IRS/PI3K/AkT, IRS/ERK, and mTOR. Through this complex network of receptors and signaling pathways, IL-4 regulates immune responses, affecting cell proliferation, differentiation, and survival, significantly influencing the function and pathological state of the immune system.
Fig.1 Schematic diagram of IL-4 signaling pathways.1,2
Application in Veterinary Therapeutics
IL-4 therapeutic antibodies specifically bind to IL-4, inhibiting its interaction with the IL-4 receptor and thus suppressing the immune response mediated by IL-4. This inhibition helps alleviate inflammatory responses in allergic diseases, offering potential improvements in clinical symptoms for diseased animals. In atopic dermatitis treatment, IL-4 antibodies may reduce skin inflammation, alleviate itching, and enhance skin health. In asthma treatment, these antibodies may have the ability to diminish airway inflammation, reducing the frequency and severity of asthma attacks. Beyond treating allergic diseases, IL-4 antibodies may also be effective in treating immune-mediated disorders due to the diverse role of IL-4 in immune regulation.
Veterinary IL-4 Therapeutic Antibody Development Services
BioVenic provides comprehensive services for veterinary IL-4 therapeutic antibody development. Our antibody characterization services utilize various biochemical and cellular techniques to verify antibody affinity, specificity, and functionality. Additionally, antibody engineering, such as antibody caninization/felinization, affinity maturation, and Fc engineering, is a crucial part of our service to optimize antibody performance. Through these comprehensive services, BioVenic is committed to advancing the research and development of veterinary IL-4 therapeutic antibodies, offering more effective treatment options for companion animals and thereby enhancing their quality of life.
Please click the link below for more information about our veterinary IL-4 therapeutic antibody development services.
Fig.2 Antibody discovery and production methods: from mouse hybridoma to transgenic mice. (BioVenic Original)
Why Choose Us?
BioVenic offers a variety of antibody development technologies, including hybridoma, single B cell, and phage display techniques.
Our antibody characterization services, encompassing both structural and functional assessments, ensure the quality of therapeutic antibodies for veterinary use.
We provide species-specific antibody development services to maintain high affinity towards specific species, ensuring therapeutic effectiveness.
Given IL-4's critical role in regulating the immune system and promoting inflammatory responses, particularly in allergic diseases, where its levels are often abnormally elevated and closely linked to pathological states. BioVenic offers veterinary IL-4 therapeutic antibody development services. These services help explore treatment options for allergic diseases and other conditions in companion animals like canine, feline, and equine. If you have such needs in this area, please contact us immediately!
References
- Shi, Jingwei, et al. "Involvement of IL-4, IL-13 and their receptors in pancreatic cancer." International journal of molecular sciences 22.6 (2021): 2998.
- Image retrieved from Figure 2 "IL-4/IL-13 axis and their signaling transduction." Shi, Jingwei, et al., 2021, used under [CC BY 4.0], the image title was changed to "Schematic diagram of IL-4 signaling pathways."