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Veterinary Mesenchymal Stem Cell-derived Extracellular Vesicle Therapy Development
With the continuous research of animal stem cells and veterinary cell therapy, scientists have discovered that many of the beneficial effects of animal MSCs in regeneration and treatment are achieved through the secretion of extracellular vesicles (EVs). Extracellular vesicles are lipid bilayer vesicles composed of exosomes, microvesicles, and apoptotic bodies. EVs produced by animal MSCs contain bioactive molecules that regulate intercellular communication, promote wound healing, and play an immunomodulatory role. In recent years, there has been a growing interest in veterinary therapies focusing on mesenchymal stem cell-derived extracellular vesicles as a research target. BioVenic has introduced a comprehensive customized solution for animal extracellular vesicles and offers tailored services for researchers working on extracellular vesicle therapies. We have a deep understanding and extensive knowledge of vesicle structure, classification and regulation and are dedicated to addressing various scientific challenges in this field.
Fig.1 The Production of Extracellular Vesicles and the Process of Intercellular Information Transmission.1,2
MSC-derived Extracellular Vesicle Analysis
BioVenic supports multidisciplinary collaboration to advance projects related to the development of MSC-EVs therapies and provides clients with one-stop customized analytical services. From the generation, isolation, purification and identification of extracellular vesicles, our dedicated technical team standardizes the process to ensure that research is completed under the guarantee of a rigorous scientific system. With our rich scientific research background in the field of animal stem cells and the detection and analysis of cell-related secretions, we are committed to providing customers with diverse solutions to effectively unravel the mysteries of MSC-EVs.
| Category | Size | Density | Feature |
| Exosomes | 40-100 nm | 1.13 g/mL - 1.19 g/mL | It is imported via the endocytosis-extraction pathway and released via a p53-regulated efflux. It is controlled by cytoskeletal activation pathways but is not affected by calcium. |
| Microvesicles | 100-1000 nm | 1.04 g/mL - 1.07 g/mL | It is formed by budding from the outside of the cell membrane, a process that involves cytoskeletal reorganization and is also dependent on intracellular calcium ion concentration. |
MSC-EV Action Mechanism and Biodistribution Analysis
BioVenic specializes in providing research services on EV biodistribution and targeting mechanisms in animals for the development of MSC-EV-based therapies. Using fluorescent labeling and imaging technology, we track and record the entire process of EV action. We are dedicated to exploring and analyzing the therapeutic mechanisms of EVs through analysis. We actively promote the preclinical research aspect of therapy development, enabling clients to fully understand the biological function of EVs as communication carriers for animal MSCs to transmit supportive signals from the tissue microenvironment.
Applications of MSC-EV in Animal Disease Treatment
| Field | Function | Application |
| Regeneration |
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| Delivery |
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| Immunomodulation |
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Why Choose Us?
Comprehensive Extracellular Vesicles Research Services
BioVenic provides comprehensive characterization services for extracellular vesicles derived from animal mesenchymal stem cells. Its related technical platform is complete and top-notch.
Expert in Animal Cell-related Fields
BioVenic has many years of experience in providing animal cell-related research services and continuously optimizes and improves its technology to ensure that the experimental results are accurate and reliable.
BioVenic has noticed the crucial role and extensive potential of animal MSC-EV in veterinary cell therapy. Leveraging its advanced animal mesenchymal stem cell-derived extracellular vesicle research technology platform, BioVenic offers top-notch solutions for researchers. We integrate specific scientific research services to address all EV-related research challenges for clients, encompassing generation, separation, characterization, and functional mechanism exploration. For further information and quotations, please do not hesitate to contact us.
References
- Image retrieved from Figure 1 "Mesenchymal stem cell (MSC) extracellular vesicle (EV) formation and messaging." Bray et al., 2021, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "The Production of Extracellular Vesicles and the Process of Intercellular Information Transmission".
- Bray, Eric R., et al. "Extracellular vesicles as therapeutic tools for the treatment of chronic wounds." Pharmaceutics 13.10 (2021): 1543.