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Veterinary Therapeutic Protein and Peptide Mammalian Cell Display Platform
Mammalian cell display is a potent cell-based technology generally used in biotechnology and bioengineering for discovering and optimizing proteins and peptides. This technique involves presenting diverse libraries of protein variants on mammalian cell surfaces, allowing for the selection of proteins/peptides with specific desired traits through advanced cell sorting methods, such as flow cytometry. BioVenic, provides comprehensive services in the discovery of veterinary therapeutic proteins and peptides, supporting our clients in advancing their research and development endeavors with precision and efficiency.
Mammalian Cell Display Overview
BioVenic has pioneered an advanced mammalian cell display platform specifically designed for the obtaining of veterinary therapeutic proteins and peptides. It leverages the natural cellular machinery of mammalian cells to produce and display recombinant proteins or peptides, accelerating the research of their interactions and function in a system that closely mimics the in vivo environment.
Fig.1 The veterinary therapeutic protein and peptide mammalian cell display platform. (BioVenic Original)
Mammalian Cell Display Services
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Mammalian Cell Display Features
- Proteins or peptides are expressed on the surface of mammalian cells, allowing for direct interaction with target ligands or other molecules in a physiological context.
- Allows for the construction of large libraries with diverse variants of proteins or peptides, which can be screened against various targets.
- Mammalian cells can perform complex post-translational modifications (e.g., glycosylation, phosphorylation), which are crucial for the proper folding and function of many therapeutic proteins and peptides.
- The display system enables high-throughput screening for binding affinity and specificity by directly evaluating interactions in a biologically relevant environment.
- Facilitates the isolation of individual clones that exhibit high binding affinity and specificity, which can be further characterized and optimized.
BioVenic offers other cell-based display platforms, including bacterial display platform, and yeast display platform. Please find the following links to learn more about our cell-based display platforms.
Mammalian Cell Display Service Workflow
The workflow for developing therapeutic proteins and peptides using mammalian cell display starts with an initial consultation to understand the client's needs and define the project scope. Next, we design and construct a diverse library of protein or peptide variants, ensuring they are optimized for expression in mammalian cells. The constructed library is then screened against target ligands to identify promising candidates. We analyze the binding interactions to evaluate affinity and specificity, select high-performing clones, and compile the results into a detailed report. Finally, we provide post-service support, including follow-up consultations and technical assistance, to ensure the successful progression of the project.
Fig.2 The service workflow of veterinary therapeutic protein and peptide mammalian cell display. (BioVenic Original)
Why Choose Us?
BioVenic has established a cutting-edge mammalian cell display discovery platform for veterinary therapeutic protein and peptide development. This advanced platform integrates state-of -the art mammalian cell technology with our extensive expertise in therapeutic protein and peptide engineering.
Mammalian cells provide a more natural environment for protein expression, which can lead to a more accurate representation of protein functionality and interactions compared to other systems like bacterial or yeast display.
Proteins and peptides expressed in mammalian cells are often less likely to be recognized as foreign by the host immune system compared to those produced in non-mammalian systems.
BioVenic offers a tailored, all-in-one solution for developing veterinary biological macromolecular drugs. Utilizing advanced mammalian cell display technology, we excel in discovering therapeutic proteins and peptides for animal health. This sophisticated cell-based approach is essential for efficient protein and peptide discovery and screening. For any inquiries about this technology, don't hesitate to contact us.