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Veterinary Therapeutic Protein and Peptide Rational Design Service
Rational design for discovering proteins and peptides involves a systematic approach to creating molecules with specific functions or properties, guided by an in-depth elucidation of their structure and interactions. It leverages a detailed recognition of protein and peptide structures, combined with computational predictions and experimental validation, to engineer protein and peptide candidates with targeted functions and properties. Based on this, BioVeinc has established a cutting-edge rational design platform to enhance the discovery of veterinary therapeutic proteins and peptides for livestock, poultry, aquaculture, and companion animals. By elucidating the structures of target proteins and leveraging advanced computer-aided techniques, BioVeinc supports clients in the discovery and optimization of proteins and peptides tailored for veterinary therapeutics.
Rational Design Platform Overview
Up to now, a diverse array of veterinary recombinant proteins and peptides constitutes the majority of approved macromolecule medicines and is used across a wide range of species, including pets, poultry, and livestock. These include cytokines, plasma proteins, enzymes, hormones, antimicrobial peptides, and anticancer peptides. Recombinant technology has become essential for developing novel therapeutic proteins and peptides for animal health. By employing rational design in protein and peptide generation, we can precisely control and confer specific functions, thereby enhancing our understanding of the interplay between protein structure and function. This technology is based on the concept that there are an increasing number of protein structures, biochemical data, reliable models, and computational methods available. To enhance preclinical research services for veterinary protein and peptide drug development, BioVenic offers a ground-breaking rational platform to assist clients in the engineering of therapeutic recombinant proteins and peptides for animals.
Fig.1 The overview of veterinary therapeutic protein and peptide rational design platform. (BioVenic Original)
Structural Determination Services
Rational design starts with a thorough analysis of the target protein-protein interactions, including understanding the 3D structure, active sites, and interaction patterns with other molecules. BioVenic offers a variety of techniques to analyze the structure of target proteins, including X-ray crystallography, nuclear magnetic resonance (NMR) technology, and cryo-electron microscopy (Cryo-EM).
| Description | Services | |
|---|---|---|
| X-rays Crystallography | It is a technique used to determine the three-dimensional structure of proteins and peptides. The sample is first crystallized, and then X-rays are directed at the crystal. By analyzing the diffraction patterns of the X-rays, our team can infer the spatial arrangement of atoms within the molecule. |
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| NMR | NMR spectroscopy uses the magnetic properties of atomic nuclei to study the structure and dynamics of proteins and peptides. NMR can be performed in solution, allowing the investigation of molecular dynamics. |
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| Cryo-EM | Cryo-electron microscopy (Cryo-EM) is a technique used to observe proteins and peptides in a near-native state. Samples are rapidly frozen to preserve their structure and imaged using an electron microscope. The resulting images are used to reconstruct the 3D structure. |
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Computer-Aided Design Services
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Bioinformatics
Bioinformatic tools leverage system knowledge to create protein and peptide libraries more likely to bind specific targets. BioVenic offers sequence libraries and improved processing tools, enabling the development of efficient, user-friendly pipelines. It facilitates the discovery and development of therapeutic proteins and peptides in veterinary medicine. -
Machine Learning
AI is advancing towards integrating molecular recognition across proteins, peptides, nucleic acids, small molecules, and other biomolecules. BioVenic utilizes machine learning to predict peptide-protein interactions and binding residues, improving binding affinity databases and optimizing the rational design of therapeutic proteins and peptides. -
Physics-based Simulation
Physics-based simulations are crucial in rational drug design for peptides and proteins, offering insights into bound states and the associated thermodynamic and kinetic properties. Despite challenges with model accuracy, sampling strategies, and computational costs, these simulations provide valuable data on properties like Kd, Kon, and Koff once the structure is known. BioVenic applies these simulations to address limitations in handling chemical changes and posttranslational modifications, enhancing the development of therapeutic proteins and peptides. -
Docking
In peptide and protein drug development, docking services are integral to rational design. Docking predicts how proteins and peptides, interact with target proteins/small molecules by modeling their binding affinity and orientation within the protein's active site. BioVenic utilizes this technology to forecast the binding affinity between therapeutic proteins/peptides and their targets/receptors. This insight aids in optimizing therapeutic candidates and understanding potential interactions.
Fig.2 The computer-aided design services in veterinary therapeutic protein and peptide rational design platform .1,2
Modification and Optimization Services
- Site-Directed Mutagenesis
Utilizing our structural analysis techniques, we precisely determine which peptide residues are essential and which can be substituted by studying the structure-activity relationship. BioVenic provides the site-directed mutagenesis service, intentionally altering a specific amino acid in the sequence to create variants using quick change PCR, CRISPR/Cas9-directed mutagenesis, and oligonucleotide-directed mutagenesis. By replacing or modifying amino acid residues that contribute less to peptide activity; while retaining key active sites, we enhance the peptide's activity and reduce potential side effects.
- Related Modification Services
BioVenic provides related modification services. The optimization and modification of veterinary therapeutic proteins and peptides is a complex but crucial process. It involves multiple considerations, including enhancing the stability, activity, and specificity of peptides, as well as reducing their immunogenicity and toxicity, thereby making them more effective and safer therapeutic agents.
BioVenic offers more comprehensive services to modify and optimize therapeutic proteins and peptides. For more services, please click the link below to learn more details.
- Veterinary Therapeutic Protein Structure Optimization
- Veterinary Therapeutic Peptide Structure Optimization
Service Workflow
BioVenic provides a specialized rational design platform to discover innovative veterinary therapeutic proteins and peptides, supporting comprehensive service for veterinary drug preclinical research. The workflow begins with consultations to define project goals and contract signing. Structural determination follows, using advanced techniques to elucidate target molecules. Computer-aided design then creates and simulates new variants based on structural data. This is followed by modification and optimization to enhance therapeutic properties. Finally, a comprehensive report detailing the design process, findings, and recommendations is delivered to the client.
Fig.3 The service workflow of veterinary therapeutic protein and peptide rational design platform. (BioVenic Original)
Why Choose Us?
Customized Service
Our rational design is tailored to each client' specific need for veterinary proteins/peptides discovery.
Diverse Structural Analysis Methods
Various technologies aid in a deeper understanding of the binding interfaces of protein-protein interactions.
Flexible Computer-aided Design
We utilize advanced bioinformatics and structural biology technologies, allows for precise design.
Precise Modification and Optimization
We offer precise modification solutions, ensures the successful optimization of veterinary therapeutic proteins and peptides.
Rational design is a highly specialized method of drug design, relying on a thorough understanding of biomolecular structures and precise molecular design, especially in the field of protein-protein interactions. BioVenic has established a platform for rational design in the discovery of veterinary therapeutic proteins and peptides, applying advanced technology and accumulating extensive experience to support the development of animal health. If you have such needs, please do not hesitate to contact us!
References
- Chang, Liwei, et al. "Towards rational computational peptide design." Frontiers in Bioinformatics 2 (2022): 1046493.
- Image retrieved from Figure 1 "Peptide modeling requires synergy between multiple computational techniques and experiments". Chang, Liwei, et al., 2022, used under CC BY 4.0, the title was changed to "The computer-aided design services in veterinary therapeutic protein and peptide rational design platform".