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Veterinary Vaccine Formulation Development by Delivery System
Subunit veterinary vaccines, lacking complete pathogens, are known for their high safety profile. Nucleic acid veterinary vaccines, easy to design and manufacture, possess the capability to induce both humoral and cellular immune responses. However, in comparison to traditional veterinary vaccines, both subunit and nucleic acid veterinary vaccines exhibit lower immunogenicity. To support you in developing delivery systems, BioVenic has established a research platform designed to explore and optimize delivery systems, ensuring that veterinary vaccines smoothly reach the areas where immune responses need to be activated.
Types of Common Vaccine Delivery System
Biovector
Modified forms of viruses or bacteria, serving as carriers for stimulating immune responses, effectively transport and release antigens. This type of vaccine mimics the natural infection process closely, presenting antigenic material to the host immune system, inducing both humoral and cellular immunity, and even mucosal immunity.
| Types of Common Virus Vector | Types of Common Bacterial Vector |
|---|---|
| Lentivirus | Lactobacillus spp. |
| Adenovirus | Salmonella spp. |
| Adeno-associated virus (AAV) | Listeria monocytogenes |
Liposome
Liposomes are small, lipid-based vesicles composed of one or more lipid bilayers encapsulating water-soluble substances. Since their discovery, they have been widely employed as vaccine delivery carriers. Encapsulating antigens within liposomes can transform soluble antigens into particulate forms, facilitating their capture by professional antigen-presenting cells. Additionally, liposomes can provide a depot effect to enhance the long-term retention and sustained release of antigens at the site of administration.
Nanoparticle
Lipid Nanoparticle
Fig.1 Lipid nanoparticles as nucleic acid carriers. 1
Polymeric Particle
Inorganic Particle
Our Services
Delivery System Production
BioVenic provides delivery system preparation services for veterinary vaccine development, aiming to customize vaccine delivery vehicles to improve vaccine efficacy and stability. We design and manufacture a variety of delivery systems based on client needs and veterinary vaccine characteristics.
| Virus Vector | Bacterial Vector | Liposome |
| Lipid Nanoparticle | Polymeric Particle | Inorganic Particle |
Size Manipulation
The size of veterinary antigens is an important factor influencing antigen transport and efficient uptake by antigen-presenting cells. BioVenic offers a service for adjusting the size of veterinary vaccine delivery systems, allowing your veterinary vaccine to have higher immune efficiency in the body.
| Types | Description |
|---|---|
| Homogenization | Breaking down larger particles into smaller ones in a homogenizer, followed by extrusion through a filter above the critical temperature to obtain smaller particles with a more uniform size distribution. The particle size depends on the filter's pore size and the number of recirculations. |
| Sonication | Ultrasonication can be used to control the size, breaking down larger particles into smaller ones above the phase transition temperature. |
Modification
Unmodified liposomes have certain limitations, such as a lack of targeting selectivity, short circulation time in the bloodstream, and in vivo instability. In contrast, inorganic nanoparticles need to be modified to alter their physicochemical properties to improve their biocompatibility. BioVenic provides modification services for veterinary vaccine delivery systems to enhance their properties with the aim of overcoming these drawbacks.
| Types | Description |
|---|---|
| Physicochemical Property Adjustment | Most hard nanoparticles do not have inherent solubility. Surface ligands are used for modification to enable their dissolution or stability in aqueous environments. |
| Targeted Modification | Small molecule ligands, peptides, or biomolecules such as proteins are attached to the surface of these delivery systems to provide a wide range of features, including cell or tissue targeting, improving cellular uptake, and antigen presentation in vaccine development. |
Analysis and Characterization
BioVenic has established a technology platform for comprehensive analysis of nanoparticles before and after encapsulation, including visual appearance, size distribution, stability, encapsulation efficiency, encapsulation efficiency analysis, in-vitro release profile analysis, and release rate.
| Transmission Electron Microscopy (TEM) | Dynamic Light Scattering (DLS) |
| Zeta Potential Analysis | High Performance Liquid Chromatography (HPLC) |
Why Choose Us?
BioVenic offers a variety of veterinary vaccine delivery systems for animals.
Size adjustment services enhance the delivery efficiency of veterinary vaccines.
Effective modification services provide veterinary vaccines with increased stability and immunogenicity.
The development of delivery systems is an essential component in developing veterinary vaccines, especially in recent years with the emergence of novel veterinary vaccines. To enhance the immunogenicity of these vaccine antigens and improve the efficiency of veterinary vaccine immunization, BioVenic provides veterinary vaccine delivery system development services. This allows you to have complementary services available after completing antigen-related processing. If you have a need for these services in veterinary vaccine development, please contact us!
References
- Tenchov, Rumiana, et al. "Lipid nanoparticles - from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement." ACS nano 15.11 (2021): 16982-17015.
- Marasini, N., et al. "Liposomes as a vaccine delivery system." Micro and Nanotechnology in vaccine Development. William Andrew Publishing, 2017. 221-239.
- Hess, Krystina L., et al. "Designing inorganic nanomaterials for vaccines and immunotherapies." Nano Today 27 (2019): 73-98.