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Veterinary Viral Proteomics and Metabolomics Services
The proteins on the exterior of veterinary viral particles play a crucial role in infecting host animal cells, including binding to the surface receptors of host cells, mediating virus entry into cells, and manipulating immune evasion. The types and structures of these veterinary viral surface proteins vary among different viruses. Proteomics and metabolomics provide robust support for identifying the types and structures of viral surface proteins. BioVenic's veterinary viral proteomics and metabolomics services, based on various advanced technologies, help customers characterize the surface structure and protein composition of viral particles, as well as understand the interactions between viruses and host cells.
Veterinary Viral Proteomics Services
Through our proteomics technology platform, we help customers in the comprehensive identification and quantification of veterinary viral proteins, thereby revealing the types and structures of viral surface proteins. Our services encompass sample preparation, protein separation, immunoprecipitation, MS analysis (such as LC-MS/MS), and bioinformatics analysis. We match the identified proteins with databases, ultimately providing customers with detailed information on the composition and structure of surface proteins. To meet customers' quantitative analysis needs, we also offer isotope labeling services, further enhancing their understanding of changes in viral surface proteins.
Fig. 1 The general workflow of proteomics experiments.1
Veterinary Viral Metabolomics Services
Through our metabolomics technology platform, we help customers analyze the veterinary viral metabolites within infected cells, providing crucial information for the identification of viral surface proteins. Our services encompass sample preparation, isotope labeling, metabolite extraction, NMR or MS, and data analysis.
Fig. 2 The general workflow of metabolomics experiments.2
Featured Veterinary Viral Proteomics and Metabolomics Platforms
By integrating proteomics and metabolomics, we provide custom, one-stop veterinary viral surface protein (especially glycoprotein) identification and structural analysis services. To meet customer's specific requirements and research objectives, we employ a variety of advanced detection technologies, including MS, LC-MS, HDX-MS, LC-MS/MS, MALDI-MS, and NMR. Surrounding these technologies, we offer several distinctive services.
LC-MS/MS
Using LC-MS/MS, we help customers identify and quantify extracted veterinary viral proteins. LC-MS is employed to separate and detect veterinary viral metabolites. Our LC-MS/MS-based proteomics and metabolomics approach aids customers in gaining in-depth insights into the structural aspects of viruses.
HDX-MS
In proteomics and metabolomics services based on hydrogen-deuterium exchange mass spectrometry (HDX-MS), we exchange extracted viral proteins or metabolites with deuterium, replacing hydrogen atoms. By measuring the extent of deuterium substitution, we assist customers in studying the structure and dynamic changes of viral proteins.
Nuclear Magnetic Resonance
Utilizing NMR techniques, we conduct two-dimensional and three-dimensional experiments on protein samples, helping customers obtain high-resolution structural information. Additionally, through NMR spectra, we identify and quantify metabolites, aiding customers in the analysis of metabolic pathways and concentrations of metabolites.
MALDI-MS
For proteomics analysis of viral proteins, we co-crystallize samples with a matrix and induce ionization of proteins in the sample through laser radiation, obtaining the mass-to-charge ratio of proteins using MALDI-MS. When analyzing small-molecule metabolites, we use MALDI-MS directly, helping customers identify and quantify them.
Veterinary Viral Proteomics and Metabolomics Service Workflow
Applications
Vaccine Development
Identification of potential vaccine candidates based on surface antigens of veterinary viruses.
Antiviral Drug Development
Discovering targets for drug development based on the surface structure and composition of viral particles.
Disease Mechanisms Elucidation
Study the molecular mechanism of veterinary viral infection by determining protein structure and protein types.
Why Choose Us?
- Cutting-edge Technology: We utilize advanced techniques such as MS, LC-MS, and HDX-MS to provide customers with precise and detailed proteomic and metabolomics analyses.
- Customized Projects: Our services are entirely customized to meet the protein characterization needs of customers for various animal viruses, including those affecting livestock, companion animals, and poultry.
- Integrated Analysis: Both proteomics and metabolomics are effective methods for identifying viral protein types and analyzing protein (glycoprotein) structures. We integrate the strengths of both methods to deliver more accurate reports to our customers.
Proteomics and metabolomics technologies have experienced rapid development in recent years, becoming extensions and elevations of the post-genomic era. They provide comprehensive and systematic approaches for studying veterinary viral surface antigens. Committed to fully deciphering the protein composition and structure of veterinary viruses, BioVenic offers veterinary viral proteomics and metabolomics services, contributing to advancements in veterinary research and the development of effective strategies against viral infections. Contact us for more details on our services.
References
- Dupree, Emmalyn J., et al. "A critical review of bottom-up proteomics: the good, the bad, and the future of this field." Proteomes 8.3 (2020): 14.
- Al-Sulaiti, Haya, et al. "Metabolomics Approaches for the Diagnosis, Treatment, and Better Disease Management of Viral Infections." Metabolites 13.8 (2023): 948.
- Maxwell, Karen L., et al. "Viral proteomics." Microbiology and Molecular Biology Reviews 71.2 (2007): 398-411.