Mouse Anti-Canine Actinin-Alpha 2 Monoclonal Antibody

Actinin-alpha2 (ACTN2) is an essential component of the muscle cytoskeleton, particularly abundant in fast-twitch muscle fibers. It is a member of the actinin family of proteins, which are characterized by their antiparallel dimer formation and their role as cross-linkers of actin filaments. ACTN2 contributes to the stability of muscle cells by connecting the actin cytoskeleton to integrins and other structural proteins within the muscle fiber. This protein is crucial for muscle contraction and maintaining the structural integrity of muscle tissue. ACTN2's function in muscle is so significant that mutations in the ACTN2 gene have been associated with various muscular disorders, including certain types of congenital myopathies.