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Veterinary Therapeutic Protein and Peptide Identification and Characterization
The characterization and identification of veterinary therapeutic proteins and peptides are crucial for ensuring their safety, efficacy, and quality, making them essential steps in the preclinical research of veterinary medicine. This process involves a variety of analytical techniques and methods. BioVenic offers comprehensive veterinary therapeutic protein and peptide characterization and identification services, utilizing state-of-the-art technology and equipment. Our services help clients gain a thorough understanding of the physicochemical properties, structure, functionality, and purity of these therapeutic agents across various applications, including livestock, poultry, aquaculture, companion animals, and economic insects.
Fig.1 Structure of proteins and peptides. 1,2
Protein and Peptide Identification and Characterization Overview
Proteins are direct products of the genome and serve as complex biomolecules and macromolecules within organisms. Their structure comprises one or more elongated polypeptide chains, intricately folded into specific shapes that determine their function. Peptides, on the other hand, are shorter chains formed by sequences of amino acid residues. Each amino acid has a distinct mass and properties, contributing to the protein's unique functionality. In veterinary therapeutic protein and peptide analysis, accurate identification and characterization are crucial for developing effective therapies. BioVenic offers comprehensive and highly sensitive services for the identification and characterization of veterinary therapeutic proteins and peptides. Our state-of-the-art techniques and advanced equipment ensure accurate and detailed analysis, supporting the preclinical research of veterinary therapeutic proteins and peptides for global clients.
Therapeutic Protein and Peptide Sequence Analysis
BioVenic offers comprehensive sequence analysis services for veterinary therapeutic proteins and peptides, crucial for understanding their function, activity, and interactions with other biomolecules. Our team examines amino acid sequences, identifying key features such as active sites, binding domains, and post-translational modifications. This detailed analysis supports the rational design of therapeutic interventions, optimizes protein and peptide efficacy, and enhances their therapeutic potential in veterinary medicine. Our analysis includes:
| N-terminal Sequencing | C-terminal Sequencing | Peptide Mapping |
| Peptide Mass Fingerprinting | Amino Acids Composition Analysis | De novo Sequencing |
Veterinary Therapeutic Protein and Peptide Surface Plasmon Resonance (SPR) Analysis
Surface Plasmon Resonance (SPR) assay is a label-free, real-time, optical biosensor technique used to quantify the affinity and kinetics of biomolecular interactions. The SPR binding assay process begins by capturing one binding partner (the "ligand") to a chip surface and then injecting a solution-phase binding partner (the "analyte") over the surface. SPR service at BioVenic offers an added benefit to our characterization capabilities providing high-throughput, real-time, label-free affinity and kinetic characterizations on therapeutic proteins and peptides. Whether you are studying protein-protein interactions or advancing hit-to-lead protein and peptide drug preclinical research, our SPR binding assay support can guide you toward your research and development goals. Our offerings include:
| Kinetic Analysis | Affinity Determination | Stoichiometry |
| Competition | Cooperativity | Reversibility |
Veterinary Therapeutic Protein and Peptide Post-Translational Modification Analysis
Post-translational modification analysis of veterinary therapeutic proteins and peptides focuses on identifying and quantifying chemical changes occurring in protein and peptide molecules that are crucial for the function, stability, and interaction of proteins. BioVenic offers post-translational modification analysis services for veterinary therapeutic proteins and peptides, providing precise analysis to help clients understand the biological functions of proteins and peptides, and offering key information for the development of veterinary therapeutic proteins and peptides. Our service content includes:
| Oxidation | Deamidation | Glycosylation | Phosphorylation |
| Methylation | Ubiquitination | Acetylation | Lipidation |
Veterinary Therapeutic Protein and Peptide High Order Structure Characterization
The higher-order structure characterization service provides a detailed analysis of the structure of veterinary therapeutic proteins and peptides, including the identification of protein and peptide folding, conformation, aggregation, and oligomeric state. BioVenic offers higher-order structure characterization services for veterinary therapeutic proteins and peptides, utilizing advanced techniques such as circular dichroism, nuclear magnetic resonance, and X-ray crystallography to assist clients in understanding the functional mechanisms, folding dynamics, and interactions with other molecules of proteins and peptides. Our services include:
| Folding Analysis | Conformation Analysis | Aggregation Analysis |
Veterinary Therapeutic Protein and Peptide Structural Biology Analysis
Integrated structural biology analysis of veterinary therapeutic proteins and peptides is crucial for understanding their three-dimensional structures and functional mechanisms. BioVenic provides comprehensive structural biology analysis services tailored for veterinary therapeutic proteins and peptides preclinical research. Our structural biologists are experienced in working flexibly with you to design a program or study from our comprehensive suite of assays and services that fully support your research goals, resources, and project criteria. Our offerings include:
| Visual Representation of Structure | Structure Predictions | Applications of Structural Biology |
Veterinary Therapeutic Protein and Peptide Basic Property Analysis
Basic property analysis service aims to evaluate the basic physical and chemical properties of veterinary therapeutic proteins and peptides, such as solubility, melting point, viscosity, and charge heterogeneity. By integrating various analytical techniques, such as dynamic light scattering, isoelectric focusing, and capillary electrophoresis, BioVenic provides comprehensive property analysis services for veterinary therapeutic proteins and peptides, helping to ensure the quality and performance of veterinary therapeutic proteins and peptides.
| Molecular Weight | Charge Heterogeneity Analysis | Stability | Isoelectric Point Determination |
| Solubility and Melting point | Dynamic Light Scattering (DLS) Analysis | Viscosity | Extinction Coefficient Determination |
Veterinary Therapeutic Protein and Peptide Bioactivity Analysis
Bioactivity analysis of veterinary therapeutic proteins and peptides is crucial for evaluating their efficacy and functional properties. BioVenic provides a full range of services, including in vitro and in vivo assays, receptor binding studies, enzymatic activity assessments, and cellular response evaluations. Our thorough bioactivity analysis ensures the potency and safety of veterinary therapeutics, supporting the development of effective and dependable veterinary therapeutic proteins and peptides.
| In vitro | In vivo | Receptor Binding | Enzymatic Activity |
Veterinary Therapeutic Protein and Peptide Biophysical Property Analysis
Analyzing the biophysical properties of veterinary therapeutic proteins and peptides is essential for assessing their stability, folding, and interactions with other molecules. BioVenic utilizes advanced techniques to measure binding properties and characterize interactions among small molecules, nucleic acids, lipids, sugars, peptides, and proteins. We provide comprehensive data, including, stoichiometry, binding reversibility, and thermodynamic parameters. This detailed analysis supports our clients in advancing their preclinical research and optimizing their therapeutic candidates.
| Mass Spectrometry | Isothermal Titration Calorimetry (ITC) | Nuclear Magnetic Resonance (NMR) | Microscale Thermophoresis (MST) |
Service Workflow
At BioVenic, our therapeutic protein and peptide identification and characterization service follows a streamlined workflow. We start with a consultation to understand your needs and design a tailored project plan. After finalizing the contract, our team executes the analysis using advanced techniques to identify and characterize your samples. We then deliver comprehensive reports detailing our findings and recommendations. Post-delivery, we provide after-sales service and technical support to address any questions and ensure your satisfaction with the results.
Fig.2 The service workflow of veterinary therapeutic protein and peptide identification and characterization. (BioVenic Original)
Why Choose Us?
BioVenic possesses an array of advanced technologies and equipment, offering clients a comprehensive solution for the characterization and identification of veterinary therapeutic proteins and peptides, ranging from sequence analysis to higher-order structure and post-translational modification analysis.
We understand that each veterinary therapeutic protein and peptide project is unique, and we provide customized services based on the specific needs of our clients, designing the most suitable experimental plan to ensure that each analysis delivers the most valuable information.
BioVenic ensures that every analysis strictly adheres to quality control standards and optimizes the process for characterizing and identifying veterinary therapeutic proteins and peptides, guaranteeing a rapid response to client needs and timely delivery of accurate and reliable analysis results.
BioVenic offers comprehensive characterization and identification services for veterinary therapeutic proteins and peptides, assisting our clients in thoroughly understanding their structure, function, and stability. Whether it's confirming molecular integrity, assessing biological activity, or ensuring product safety, BioVenic is dedicated to offering dependable and accurate analytical solutions. If you have any such needs, please connect with us promptly.
References
- Tertis, Mihaela, et al. "Electrochemical peptide-based sensors for foodborne pathogens detection." Molecules 26.11 (2021): 3200.
- Image retrieved from Figure 1 "Structural composition of proteins and peptides".Tertis, Mihaela, et al., 2021, used under CC BY 4.0, the title was changed to "Structure of proteins and peptides".