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Animal Bile Metabolomics
Background
BioVenic offers comprehensive metabolomics solutions for global customers with scientific research requirements in animal bile composition and differential metabolism analysis. We enable small molecule discovery and conduct in-depth analysis of specific biomarkers in metabolic samples. This is achieved by designing experimental protocols that incorporate specific combinations of technology and expertise and developing highly sensitive assays to fully explore these biomarkers.
Background
Bile acids are metabolites derived from cholesterol that have well-established roles in the animal digestion and absorption of dietary fat. It is also a key signaling molecule that coordinates glucose, lipid, and energy metabolism. The analysis of bile components and the detection of biomarkers through non-targeted animal bile metabolomics are helpful for in-depth exploration and understanding of physiological mechanisms related to the digestive process, lipid metabolism, and bile acid cycle. This has great potential to advance our understanding of the role of bile in the development of metabolic disorders and to develop new treatments for these diseases.
Fig.1 Schematic Diagram of Bile Synthesis and Metabolism. 1
Animal Bile Non-targeted Metabolomic Services
Different from targeted metabolomics analysis, non-targeted metabolomics of animal bile focuses more on exploring the composition and characteristics of bile, as well as biological information related to metabolism, such as digestive processes, lipid metabolism, and the bile acid cycle. It also provides insights into the function of the animal's biliary system and its association with lipid metabolism and bile-related diseases. BioVenic offers two main directions for animal bile non-targeted metabolomics customization services.
- Bile Composition and Metabolism Analysis
The formation of bile acids is important for maintaining cholesterol homeostasis. They can affect the absorption of dietary lipids. Its composition and dynamic changes are currently popular research topics. BioVenic provides highly customized end-to-end services. Advanced high-throughput detection technology and strict quality control ensure the delivery of high-quality animal bile non-targeted metabolomics customized services. Many metabolic transformations result in the presence of a complex mixture of biologically active and inactive forms in bile samples. BioVenic utilizes advanced methods and high-coverage standard metabolite databases to characterize and identify individual biomarkers within these mixtures.
- Bile Acid on Other Metabolic Activities
Bile acids play a crucial role in maintaining lipid metabolism, glucose metabolism, and energy metabolism in the body. Serum bile acid levels are important indicators of hepatobiliary function. Detection of multiple bile acid levels in biological samples could provide reliable markers for a broader spectrum of diseases. At the same time, an imbalance in bile acid metabolism can affect the integrity of the intestinal barrier, leading to inflammation and the proliferation of pathogenic microorganisms. Using metabolomics to characterize bile acid metabolism profiles can help study the mechanisms of animals under physiological conditions and specific diseases. This provides a scientific basis for the development of new treatments.
Flow Chart of Animal Non-targeted Metabolomics Analysis Service
Why Choose Us?
Detection technology routes focusing on specific metabolites or metabolic pathways in bile components.
Comprehensive analysis of metabolomics data in multiple dimensions based on multiple metabolic pathways and the overall metabolic network.
One-stop solution strategy for non-targeted metabolomics of animal bile.
Highly customized project plans and delivery methods on demand.
R & D team with rich experience in practical operation.
BioVenic is ready to develop custom untargeted bile metabolomics solutions for you. These solutions will help you achieve your research and biomarker validation goals using precise and well-validated methods. The high-throughput animal sample detection platform and database, established by BioVenic, covers thousands of metabolites and lipid markers. This platform can assist you in conducting comprehensive analysis and understanding of metabolic pathways and physiological processes. Moreover, it allows you to adjust the analysis direction and angle as scientific research projects progress. Please feel free to contact us for more details and inquiries about our services.
Reference
- Xie, Cong, et al. "Role of bile acids in the regulation of food intake, and their dysregulation in metabolic disease." Nutrients 13.4 (2021): 1104.