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Animal Gut Microbiota Metabolomics
The intestinal microbiome is closely related to animal health and production performance, and it has received widespread attention from researchers. The complex gastrointestinal community, composed of bacteria, viruses, protozoa, and fungi, plays an important role in the health and disease of animal hosts. The customized animal intestinal microbiome metabolomics service launched by BioVenic aims to analyze the relationship between microorganisms and their metabolites and animal growth and development, nutritional metabolism, and other life activities for customers. Furthermore, we aim to explore the interaction between intestinal microorganisms and the host. From the perspective of bioinformatics, we enable scientific researchers to comprehend the correlation between specific microbial flora and metabolic substances, as well as the investigation of nutrient metabolism and energy metabolism.
Fig.1 Different Mechanisms Linking Gut Microbes to Disease. 1
Non-targeted Metabolomics Services for Animal Gut Microbiota
BioVenic offers services for designing and implementing non-targeted metabolomics experiments. These experiments aim to describe all metabolites present in animal intestinal microbial metabolism samples and enable qualitative or even semi-quantitative detection. A biochemical technology platform, coupled with chromatography and mass spectrometry, is used to compare different samples for differential analysis in order to screen biomarkers.
- Sample Collection and Preparation
We provide sample extraction and preparation solutions according to customer project needs. After directly extracting animal intestinal microorganisms for detection, the results obtained are the results of the co-metabolism of the host and the microbial community. Enriching and extracting microbial cells from the sample and analyzing the metabolite precipitation in the microbial cells supports the study of the interaction between environmental factors, host, and microorganisms.
- Metabolite Detection
BioVenic customizes metabolic component detection and identification solutions for customers based on different samples and research needs. Through the comprehensive use of different analysis platforms, a full understanding of the metabolites in the sample can be achieved.
- Data Acquisition and Bioinformatics Analysis
BioVenic processes the acquired raw data to reduce and simplify the high-dimensional and large amounts of complex data. In order to fully utilize the potential information in the acquired data, we employ a range of systematic econometrics and multivariate statistical analysis methods in our data statistical analysis services. These methods are combined with a self-constructed database to identify differential metabolites. At the same time, a metabolic pathway analysis was conducted using bioinformatics background materials to explore the specific correlation between supply pathways, metabolic pathways, and traits.
Please find more detailed information with gut microbiota omics solutions with the following links:
Flow Chart of Animal Non-targeted Metabolomics Analysis Service
Summary of Metabolite Functions of Livestock Intestinal Microorganisms
| Metabolites | Functions | Bacteria |
|---|---|---|
| Short-chain fatty acids | Provide energy for epithelial cells, participate in cholesterol synthesis, regulate water, and salt absorption, and participate in immune regulation. | Firmicutes Clostridium group |
| Phenols, benzoyl, and phenyl derivatives | Detoxify and regulate intestinal microbial composition and activity. | Bifidobacterium, Pediococcus, etc. |
| Tryptophan metabolites | Improve epithelial cell function and regulate cytokine expression. | Escherichia coli, Clostridia, etc. |
| Ammonia and hydrogen sulfide | Affect host immunity and reduce livestock production performance. | Genetic bacterial species, Shigella, Escherichia coli, Klebsiella spp., etc. |
| Bile acids | Promote the absorption of lipids and fat-soluble vitamins, participate in the regulation of intestinal immunity and metabolism, and influence the composition of the microbial community. | Lactobacilli, Bifidobacteria, Enterobacteriaceae, etc. |
| Choline metabolites | Regulate lipid metabolism and glucose metabolism, liver and heart disease-related marker metabolites | Bifidobacterium, Clostridium tenella, etc. |
| Lipids | Affect intestinal permeability, regulate glucose metabolism, and regulate lipoprotein synthesis. | Bifidobacterium, Lactobacillus, etc. |
Why Choose Us?
One-stop customized animal gut microbiota metabolomics solution.
An in-depth analysis report of the application potential and mechanisms of the intestinal microbiome.
Animal metabolomics experimental design that is highly consistent with scientific research goals.
BioVenic offers personalized metabolome analysis services for researchers studying the fundamental life activities associated with intestinal microorganisms and animal nutritional metabolism, energy supply, reproduction, and production. Our expert team offers comprehensive solutions and extensive experience in animal metabolomics projects. We enable you to analyze the impact of intestinal microorganisms on animal growth and development, animal nutrition and metabolism, animal health and diseases, as well as obtain precise and detailed metabolic data along with bioinformatics analysis reports. Please feel free to contact us and inquire to get a quote.
Reference
- Zhang, Chunye, Craig L. Franklin, and Aaron C. Ericsson. "Consideration of gut microbiome in murine models of diseases." Microorganisms 9.5 (2021): 1062.