Veterinary Fungal Antimicrobial Resistance (AMR) Solutions

BioVenic is dedicated to advancing veterinary health through our specialized antifungal drug resistance research and development services. Fungal infections in animals pose significant challenges, particularly due to the rising issue of antifungal resistance. Our comprehensive suite of services is designed to address this problem from multiple angles, utilizing advanced technologies and methodologies. We offer robust solutions in fungal antimicrobial resistance (AMR) genetics and genomics, phenotypic resistance characterization, pharmacokinetics/pharmacodynamics (PK/PD) studies, and detailed investigations into the mechanisms of antifungal resistance. Our team of experts is committed to delivering high-quality, reliable results that can guide the development of effective antifungal therapies for veterinary applications.

Veterinary Fungal Antimicrobial Resistance (AMR) Services

We offer a range of services tailored to the challenges of veterinary fungal pathogen AMR. Our customized solutions are tailored to the specific requirements of veterinary pharmaceutical research requirements. Our team of experienced scientists and researchers brings a wealth of knowledge and expertise to every project, ensuring high-quality results and actionable insights. We are committed to supporting our clients in the development of effective antifungal therapies that address the growing issue of drug resistance in veterinary medicine.

Veterinary Fungal AMR Genomic Characterization

Understanding the genetic basis of antifungal resistance is crucial for developing effective strategies to combat resistant fungal infections. Our genetics and genomics services leverage the latest sequencing technologies to provide comprehensive insights into the genetic mutations and mechanisms that confer resistance. We conduct whole-genome sequencing, transcriptome analysis, and comparative genomics to identify resistance genes and pathways. By analyzing the genetic makeup of resistant fungal strains, we can pinpoint specific mutations responsible for reduced drug efficacy. This information is vital for the development of new antifungal drugs and for improving the efficacy of existing treatments. Our genomic data is meticulously analyzed and interpreted by our bioinformatics experts, ensuring that our clients receive actionable insights tailored to their specific needs.

Veterinary Fungal AMR Phenotypic Characterization

Phenotypic resistance characterization is essential for understanding how genetic changes translate into actual resistance in fungal pathogens. BioVenic utilizes advanced techniques to assess the phenotypic resistance of fungal isolates. This involves testing fungal strains against a range of antifungal agents to determine their minimum inhibitory concentrations (MICs) and other resistance metrics. Our laboratory is equipped with advanced automation and high-throughput screening capabilities, allowing us to process large numbers of samples efficiently and accurately. By correlating phenotypic data with genetic findings, we provide a comprehensive picture of antifungal resistance, helping our clients understand the practical implications of genetic mutations. This service is invaluable for veterinary pharmaceutical companies seeking to develop or refine antifungal treatments.

Veterinary Fungal AMR PK/PD Services

Effective antifungal treatment in veterinary medicine requires a thorough understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of the drugs used. Our PK/PD services are designed to optimize antifungal dosing regimens by studying the absorption, distribution, metabolism, and excretion of drugs in animal models. We conduct in vivo and in vitro studies to characterize the PK/PD profiles of antifungal agents, ensuring that they achieve the desired therapeutic concentrations at the site of infection. By integrating PK/PD data with resistance information, we can recommend dosing strategies that maximize efficacy while minimizing the risk of resistance development. Our comprehensive in vitro, in vivo, and ex vivo PK/PD studies support the development of safe and effective antifungal therapies tailored to the unique needs of veterinary research and development.

Veterinary Fungal AMR Mechanism Studies

Understanding the mechanisms underlying antifungal drug resistance is critical for developing strategies to overcome it. BioVenic conducts in-depth studies to elucidate the mechanisms of antifungal resistance in veterinary pathogens. These mechanisms can include alterations in drug-target interactions, such as mutations that reduce drug affinity, and changes that reduce intracellular drug levels, such as the upregulation of drug efflux pumps. Our research involves a combination of molecular biology, biochemistry, and microbiology techniques to investigate these resistance mechanisms. By identifying how fungal pathogens evade antifungal drugs, we can help our clients develop more effective treatments and mitigate the spread of resistance. Our findings contribute to a deeper understanding of fungal AMR and inform the design of next-generation antifungal therapies.

Fig.2 Fungal intrinsic and acquired drug resistance.¹

Our Advantages

• Our services help identify potential targets for new antifungal agents and strategies to restore the efficacy of existing drugs.
• We provide customized bioinformatic analysis, including gene expression analysis, functional assays, and inhibitor studies to understand antifungal resistance mechanisms.
• We work closely with our clients to ensure tailored research and development solution for antifungal antimicrobial resistance.

BioVenic is dedicated to providing comprehensive and innovative solutions to tackle veterinary fungal antimicrobial resistance. Our services in fungal AMR genetics and genomics, phenotypic resistance characterization, PK/PD studies, and mechanism studies offer a holistic approach to understanding and combating antifungal resistance. By leveraging our expertise and state-of-the-art technologies, we empower veterinary pharmaceutical companies and researchers to understanding antifungal resistance mechanism and develop effective, targeted treatments that improve animal health and combat the threat of antifungal resistance. Please contact us to advance your antifungal research and achieve your veterinary health goals.

Reference

1. Revie, Nicole M., et al. "Antifungal drug resistance: evolution, mechanisms and impact." Current opinion in microbiology 45 (2018): 70-76.