Antimicrobial Resistance (AMR) in Companion Animals

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Antimicrobial Resistance (AMR) in Companion Animals

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Identification and Characterization Antimicrobial Susceptibility Testing PK/PD Services Mechanism Studies

BioVenic is dedicated to advancing veterinary science by providing specialized research services that address antimicrobial resistance to antibiotics, antifungals, and antiprotozoals. Our suite of services encompasses pathogen identification and characterization, antimicrobial susceptibility testing, pharmacokinetics/pharmacodynamics (PK/PD) studies, and mechanism studies. We aim to deliver precise, reliable, and actionable data that empower researchers to develop novel antimicrobial drugs effectively and sustainably avoiding AMR in companion animals.

Veterinary Antimicrobial Resistance (AMR) Services

By identifying the specific strain and its genetic attributes, our services can tailor treatment protocols more accurately for companion animals, enhancing their efficacy and minimizing the risk of developing resistance.

Veterinary AMR Identification and Characterization

Our pathogen identification and characterization services employ advanced testing and analysis technologies and molecular biology techniques to achieve precise identification. Our services involve isolating and analyzing pathogens such as bacteria, fungi, and parasites from companion animal infection samples. Our molecular services and phenotypic characterization services provide comprehensive insights into the genetic makeup of pathogens, including virulence factors, resistance genes, and other genomic characteristics that influence pathogenicity and resistance mechanisms.

Antimicrobial Susceptibility Testing

We provide both phenotypic methods and advanced molecular-based methods for antimicrobial susceptibility testing. Phenotypic methods involve culturing the pathogen and exposing it to different antimicrobials to observe its growth response. Techniques such as disk diffusion, broth microdilution, and E-test provide quantitative data on the minimum inhibitory concentrations (MICs) required to inhibit pathogen growth. classic methods are standardized and validated to ensure reliability and reproducibility. Our molecular AST services and MALDI-TOF MS complement phenotypic testing by providing a comprehensive understanding of antimicrobial resistance.

Classic Methods	Molecular-Based Methods	Mass Spectrometry
Dilution Disk Diffusion Test Antimicrobial Gradient Method Chromogenic Agar Media Colourimetric Test	PCR qPCR DNA-Microarrays WGS	MALDI-TOF MS

AMR PK/PD Services

Pharmacokinetics (PK) and pharmacodynamics (PD) studies are essential for understanding drug-pathogen interactions within companion animals, optimizing dosing regimens for therapeutic efficacy. Our PK service assess drug absorption, distribution, metabolism, and excretion (ADME) in companion animals, providing crucial data on drug concentration in tissues over time to determine optimal dosing intervals. Our PD service focus on the relationship between drug concentration and its effect on pathogens, evaluating bactericidal or bacteriostatic activity to identify effective doses without toxicity. Our in vitro, in vivo, ex vivo PK/PD models are vital for optimizing antimicrobial treatments to ensure efficacy and safety, minimizing resistance development, tailoring individualized therapies based on specific companion animal characteristics.

AMR Mechanism Studies

We employ advanced analytical techniques such as proteomics, transcriptomics, and bioinformatics to study resistance mechanisms, allowing to identify and characterize resistance genes, regulatory networks, and adaptive responses in pathogens. Our mechanism study services assist in developing new antimicrobial agents that target specific resistance mechanisms, designing strategies to prevent the emergence and spread of resistant strains among cats and dogs.

Common Pathogen AMR in Companion Animals
Species	Pathogen	Resistance
Dogs and Cats	Campylobacter jejuni	Aminoglycosides, Fluoroquinolones, Lincosamides, Macrolides, Tetracycline, Multidrug Resistance
	Enterobacteriaceae and Acinetobacter spp.	Penicillins, Cephalosporins, Fluoroquinolones
	Enterococcus spp.	Penicillins, Fluoroquinolones, Macrolides
	Pseudomonas aeruginosa	Fluoroquinolones, Carbapenems
	Staphylococcus spp.	Cephalosporins, Fluoroquinolones, Lincosamides, Macrolides, Penicillins, Tetracyclines
Equine	Enterobacteriaceae	Penicillins, Extended-spectrum beta-lactamase (ESBL)
Equine	Pseudomonas aeruginosa	Macrolides, Penicillins, Tetracyclines, Fluroquinolones

BioVeinc advances the field of veterinary science through our innovative antimicrobial resistance research and comprehensive services. Our services contribute to the scientific understanding of AMR in companion animals, informing future research and guiding the development of new therapeutic strategies. Please contact us to learn more about our veterinary antimicrobial resistance services in companion animals.