Animal Mesenchymal Stem Cell Secretome Solution

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Animal Mesenchymal Stem Cell Secretome Solution

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Animal MSC Secretome Biological Functions Animal MSC Paracrine Analysis Animal MSC-derived Extracellular Vesicle Analysis Animal MSC Secretome Optimization Why Choose Us?

The secretome and extracellular vesicles (EVs) derived from animal mesenchymal stem cells (MSCs) have become a popular subject among researchers in recent years. Due to the outstanding performance of stem cells in the field of regenerative medicine, EVs, which have a similar functional secretome and potential for targeted delivery, have also shown great promise in the veterinary field. Compared to cell-based therapies, the use of secretomes offers key advantages such as low immunogenicity, ease of production, processing, and storage. In addition, secretomes could regulate MSCs to alter their secretome composition to better match specific therapeutic goals, creating numerous opportunities. BioVenic offers a comprehensive range of customized services related to the animal MSC secretome to effectively meet the diverse research needs of researchers. For the regulation and analysis of paracrine effects, as well as the analysis and characterization of EVs, we rely on our sophisticated and comprehensive technology platform to tailor efficient and high-quality services.

Fig.1 MSCs Secrete through Paracrine and Extracellular Vesicles. (Carrera, et al., 2023) Fig.1 MSCs are Induced to Secrete via Paracrine and Extracellular Vesicles.^1,2

Animal MSC Secretome Biological Functions

Functions	Mechanisms
Immunomodulation	Through direct cell-to-cell interactions and the secretion of soluble factors, immune cells are inhibited from exerting immunomodulatory effects. Inhibits the proliferation of immune cells such as T and B cells, suppresses the production of neutrophils, and hinders the differentiation and maturation of monocytes. Promotes the immunomodulatory function of the MSC secretome by secreting pro-inflammatory cytokines.
Promotes Angiogenesis	Induces endothelial cell proliferation, migration, and tube formation. Inhibits endothelial cell apoptosis. Multiple growth factors in the secretome stimulate the growth rate of blood vessels in vivo.
Anti-apoptosis	Promotes the expression of antiapoptotic proteins. Decreases the expression of pro-apoptotic proteins.
Wound Healing and Tissue Repair	Releases inflammatory cytokines to induce new tissue formation. Secretes anti-fibrosis proteins to reduce scarring.
Antibacterial	Enhances phagocyte activity to regulate immunity. Releases chemokines to exert antibacterial effects.

Animal Mesenchymal Stem Cell Secretome Services

Animal MSC Paracrine Analysis

BioVenic offers in-depth research on the paracrine mechanism of animal MSC and its downstream applications. We provide detailed and professional analysis services related to the paracrine effect of MSC to researchers around the world, including secretion regulation, secretome composition, and secretion-related expression analysis. Our team of animal stem cell experts has formed a special working group to study the composition and function of bioactive factors secreted by MSC. We wholeheartedly support researchers worldwide in their projects related to secretome regulation and animal physiological processes.

Fig.2 Cytokines Involved in Paracrine Effects of MSCs. (BioVenic Original) Fig.2 Typical Cytokines Involved in Paracrine Effects of MSCs.

Animal MSC-derived Extracellular Vesicle Analysis

BioVenic relies on a comprehensive animal cell biology-related technology platform to advance projects related to animal MSC-EVs through multidisciplinary collaboration. We also offer one-stop customized analysis services for researchers. From biogenesis to separation, purification, identification, and characterization of extracellular vesicles, our laboratory technicians standardize the entire technical process and working methods to ensure that research is conducted under the guarantee of a rigorous scientific system. With our extensive scientific research background in animal stem cells and the detection and analysis of animal cells and cell-related secretions, coupled with cutting-edge high-throughput detection technologies such as flow cytometry, we are dedicated to providing our customers with solutions that efficiently unravel the mysteries of MSC-EVs.

Fig.3 Animal MSC-EVs Analysis and Characterization Technologies.

Animal MSC Secretome Optimization

BioVenic uses a variety of stimulations and conditions to optimize the secretome of animal MSCs for customers. Through physical stimulation and enhancement of the culture system, we optimize the secretome components to fully meet the requirements of different studies and different stages of research. We have extensive project experience in animal stem cell enhancement and culture system optimization. By exposing MSCs to hypoxic environments, inducing cytokines, co-culturing with other cells, and performing gene editing, we help customers modify MSCs and their secretomes.

Hypoxia Induction
Cytokine Induction

Culture Induction
Gene Editing

Why Choose Us?

We offer comprehensive customized services for animal mesenchymal stem cells, including both the cell secretome and the cells themselves.

Our professional team of experts in animal cell biology and stem cells provides technical support to customers throughout the process.

We standardize technical processes and operating methods to strictly control potential contamination and cell damage during implementation.

BioVenic offers a comprehensive range of customized solutions for the secretome of animal MSCs. We work with our customers to explore the unlimited potential of this resource in veterinary therapy research, veterinary drug development and tissue regeneration. With a comprehensive technology platform for stem cell detection and analysis, and cutting-edge high-throughput detection and screening technologies such as flow cytometry, we can efficiently and accurately execute project plans to optimize MSC paracrine, extracellular vesicle, and secretome. If you are considering incorporating stem cell secretomes into your research plan but are facing technical challenges, please contact us and we will be happy to work together to solve your research problems.

References

Image retrieved from Figure 2 "Schematic representation of induction and action of mesenchymal stem cells' secretomes." Carrera et al., 2023, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "MSCs are Induced to Secrete via Paracrine and Extracellular Vesicles."
Carrera, Alefe Luiz Caliani, et al. "The Role of Mesenchymal Stem Cell Secretome (Extracellular Microvesicles and Exosomes) in Animals' Musculoskeletal and Neurologic-Related Disorders." Veterinary Medicine International 2023 (2023).