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Veterinary Antimicrobial Resistance (AMR) Solutions
The misuse and overuse of antimicrobials in animals can lead to resistant bacteria and fungi, posing severe health risks to both animals and humans. Addressing this issue requires a comprehensive approach involving diverse scientific research and development services. BioVenic offers a range of veterinary antimicrobial resistance (AMR) services and solutions tailored for global companies and researchers to study AMR mechanisms and develop novel antibiotic alternatives.
Veterinary Antimicrobial Resistance (AMR) Services
Combatting veterinary bacterial antimicrobial resistance requires a multifaceted approach that encompasses genotypic and phenotypic characterization, susceptibility testing, PK/PD testing, and other strategic analysis. BioVenic offers a wide range of antimicrobial resistance testing and analysis services aimed at tackling veterinary bacterial AMR.
Veterinary AMR Genotypic Characterization
Genotypic characterization involves identifying the specific genes responsible for antimicrobial resistance in bacterial or fungal pathogens. By analyzing the genetic makeup of these bacteria or fungus, we can understand the mechanisms behind resistance and develop targeted strategies. Our genotypic characterization service is crucial for pinpointing resistance genes and monitoring their spread among animal populations.
Veterinary AMR Gene Discovery
Gene discovery focuses on finding novel resistance genes among bacteria and fungus that may not have been previously identified. Through advanced genomic techniques, such as whole genome sequencing, gene transcriptomics studies, we can uncover novel resistance determinants, providing valuable insights into emerging resistance trends and helping to stay ahead of potential outbreaks.
Veterinary AMR Phenotypic Characterization
Antimicrobial resistance can be non-inherited resistance, which is achieved without any genetic variation. Phenotypic characterization assesses the observable characteristics of bacteria or fungus, such as their ability to survive and grow in the presence of specific antimicrobials. Our service helps determine the actual resistance profiles of pathogens, guiding the selection of effective treatments and informing stewardship practices.
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Veterinary Antimicrobial Susceptibility Testing
Antimicrobial susceptibility testing (AST) evaluates how susceptible bacterial isolates are to various antimicrobial agents. Our testing service is essential for determine minimum inhibitory concentration (MIC) of drug candidate for microbial pathogens, selecting the most appropriate antimicrobial drug candidates for treatment, ensuring effective therapy while minimizing the risk of resistance development. We offer comprehensive AST for antimicrobial studies in the field of veterinary science.
Fig.1 Methods for Antimicrobial Susceptibility Testing.1
Veterinary AMR PK/PD Services
Pharmacokinetic and pharmacodynamic (PK/PD) services involve studying the interactions between antimicrobials and bacteria or fungus within the animal bodies. Our in vitro, in vivo, and ex vivo services help optimize dosage regimens, ensuring that antimicrobial concentrations are sufficient to eradicate pathogens without promoting resistance.
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Veterinary Antimicrobial Resistance Mechanism Studies
Our mechanism studies delve into the biological processes that pathogen resist antimicrobials. By understanding these mechanisms, we can develop strategies to counteract resistance and enhance the efficacy of existing antimicrobials.
Fig.2 General antimicrobial resistance mechanisms.
Veterinary Antimicrobial Resistance (AMR) Solutions
BioVenic provide one-stop solutions supporting your research requirements in veterinary antimicrobial resistance. Our services provide you with comprehensive insights into antimicrobial resistance mechanisms, AMR in different pathogens, and AMR in different animals.
We provide comprehensive solutions tailored to combat bacterial AMR in veterinary settings. Our solutions encompass laboratory diagnostic services, AMR research and treatment development aimed at reducing the spread of resistant bacteria and the use of antimicrobiotics in animals.
We also address antifungal resistance in veterinary fungus pathogens. Our services include identifying resistance mechanisms, testing susceptibility, and we provide effective antifungal therapy research and development services to combat resistant fungal infections among animals.
Different animal species harbor unique pathogens with specific resistance profiles. We offer specialized solutions for AMR in animal-specific pathogens, ensuring targeted and effective development of treatment and alternative therapeutic strategies for each species.
Zoonotic pathogens can transfer from animals to humans, posing significant public health risks. Our solutions for AMR in zoonotic pathogens focus on identifying resistant zoonotic strains and providing R&D services for zoonotic therapeutics development.
Commensal bacteria are part of the normal flora of animals, can act as reservoirs for resistance genes. We provide services to study AMR mechanisms in these bacteria, preventing them from becoming sources of infection or resistance transfer among animals.
BioVenic specializes in AMR research and development across various animal species, offering tailored services for each. Our comprehensive approach ensures effective research and development of antimicrobial resistance in livestock, companion animals, and aquaculture species, promoting animal health and public safety.
Food animals, such as cattle, poultry, and swine, are a major focus of our AMR solutions. We offer comprehensive services to monitor, test, and study AMR in these populations, enhance the research and development of antimicrobial alternatives in food production animals.
Companion animals, including pets like dogs and cats, can also develop resistant infections when overuse the antibiotics. Our solutions for companion animals involve preclinical diagnostic testing, treatment development and AMR mechanism studies in these beloved pets.
- AMR in Monogastric Animals
Monogastric animals, such as pigs and poultry, have unique digestive systems that affect how they process antimicrobials. We offer specialized solutions to study AMR in these species, facilitate comprehensive understanding on AMR and the development of antimicrobial therapies.
- AMR in Ruminants
Ruminants, including cattle, sheep, and goats, have complex digestive systems that influence antimicrobial efficacy and resistance development. Our services are tailored to address the specific challenges of AMR in ruminant populations.
- AMR in Aquaculture Species
Aquaculture species, such as fish and shrimp, are increasingly important in global food production. We provide solutions for AMR research services in aquaculture, ensuring the sustainability and safety of antimicrobial use in aquatic environments.
BioVenic's comprehensive range of services and solutions are designed to address the complexities of AMR across various animal species and humans as well as the environments. Using advanced scientific techniques and expert knowledge, we aim to decrease resistant pathogens, protect both animal and public health, and support responsible antimicrobial research and development in veterinary medicine. Please contact us to learn more about our veterinary antimicrobial resistance services and solutions.
Reference
- Gajic, Ina, et al. "Antimicrobial susceptibility testing: a comprehensive review of currently used methods." Antibiotics 11.4 (2022): 427.