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Veterinary Induced Pluripotent Stem Cell (iPSC) Therapy Development
Compared with other animal stem cells, animal iPSCs have increasingly flexible methods for obtaining them, and scientists consider them a valuable resource for the advancement of animal regenerative medicine and cell therapy. The basic principle of using pluripotent stem cells (PSCs) for cell therapy involves differentiating them into the desired target cell type and then transplanting the resulting tissue-specific cells into the diseased animal either as a cell suspension or a more complex tissue structure. BioVenic is collaborating with scientists to develop veterinary iPSC therapies that are more cost-effective, readily available, and rigorously controlled. Our goal is to offer cutting-edge solutions for our customers' personalized research needs and to enhance the preclinical therapy development process using advanced veterinary iPSC technology and engineering.
Fig.1 Potential Uses of iPSCs in the Treatment of Companion Animal Diseases.1,2
Animal Induced Pluripotent Stem Cell Solution
BioVenic offers customized solutions for researchers in iPSC-related cell reprogramming and technology optimization, cell culture system development, directed cell differentiation, and maintenance of cell pluripotency. Our services integrate high-throughput animal cell detection platforms, cell genome editing platforms, and animal stem cell platforms. We are dedicated to providing efficient customized services to scientists engaged in the development of veterinary iPSC therapies.
- iPSC Reprogramming
- iPSC Culture Development
- iPSC Engineering
- iPSC Differentiation
- iPSC Characterization
- iPSC Pluripotency Maintenance
Veterinary iPSC Therapy Development and Evaluation
BioVenic not only customizes high-quality experimental plans for the development of veterinary iPSC therapies for clients but also conducts comprehensive assessments of the various issues and risks of iPSC application in veterinary therapy, especially tumorigenicity. During therapy development, we evaluate the therapeutic function and potential risks to ensure the practicality and safety of the plan.
Applications of iPSCs in Animal Disease Treatment
| Species | Diseases | Origin Cell | Differentiated Cell | Administration Route | Outcome |
| Canine | Hind limb ischemia | Adult MSCs and fibroblasts | Endothelial cells | Local injections |
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| Cardiac infarction | Adult MSCs and fibroblasts | Endothelial cells | Local injections |
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| Porcine | Chronic myocardial infarction | Adult fibroblasts | piPSCs | Direct injection |
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| Osteoporosis | Fibroblasts | Osteoblast-like cells | Local cell transplantation |
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Osteochondral damage Osteoarthritis |
Adult fibroblasts | piPSC-like cells | Direct pellet transplantation |
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| Acute myocardial infarction | Adult fibroblasts | piPSCs | Direct injection |
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| Retinal damage | Fetal fibroblasts | Rod photoreceptors | Local injection |
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| Myocardial infraction | Adult MSCs | Endothelial cells | Local injections |
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| Equine | Muscle injury | Adult MSCs | eiPSCs | Intramuscular injection |
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| Musculoskeletal injury | Adult MSCs | MSCs | Injection into lesion |
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Why Choose Us?
Experts in the Field of Animal iPSCs
BioVenic has been deeply involved in the field of animal stem cell research services, in particular in the generation and maintenance of iPSCs, standardizing the basic experimental service processes to ensure reliable and reproducible experimental results.
One-stop Veterinary Cell Therapy Development
BioVenic has in-depth knowledge in the emerging scientific research field of veterinary cell therapy. Leveraging its deep expertise in cell biology and a comprehensive technology platform, BioVenic provides therapy development support and preclinical evaluation services.
BioVenic continues to focus on the cutting-edge development of veterinary cell therapy to ensure that the solutions we provide are innovative and scientifically designed. Clinical research on iPSC therapy in companion animals is still limited, and the entire field is still in its infancy. Our development solutions encompass the generation of MSCs from iPSCs and their utilization in cell therapy development, catering to various research project needs. Please contact us to initiate a discussion and commence a project.
References
- Image retrieved from Figure 3 "Potential Use of Domestic Animal iPSCs for Drug Discovery, Disease Modelling and Cell Replacement Therapy." Scarfone et al., 2020, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "Potential Uses of iPSCs in the Treatment of Companion Animal Diseases."
- Scarfone, Rachel A., et al. "The use of induced pluripotent stem cells in domestic animals: a narrative review." BMC veterinary research 16 (2020): 1-18.