Animal Cerebrospinal Fluid Metabolomics

One-stop Solution CSF Metabolomics

Animal cerebrospinal fluid (CSF) is the main component of the extracellular fluid of the central nervous system. Its metabolic composition is relatively stable and simple, and it is rich in a variety of small molecule biomarkers that can characterize and detect neurodegenerative and neurological diseases. BioVenic's animal cerebrospinal fluid omics analysis service supports researchers in discovering highly relevant biomarkers for central nervous system diseases. BioVenic relies on high-throughput metabolomics bioanalytical technology platforms, such as LC-MS, GC-MS, and ICP-MS, to comprehensively identify the metabolic components of cerebrospinal fluid. Combining modeling and database comparison, we can finally deliver metabolomics comprehensive assessment results with good reliability and high reproducibility.

Fig.1 Schematic Diagram of Cerebrospinal Fluid Metabolomics Research. ¹

One-stop Solution CSF Metabolomics

• Collection and preprocessing of cerebrospinal fluid samples.
• Applying high-throughput metabolomics techniques including NMR, LC-MS, GC-MS, DFI-MS/MS, and ICP-MS to analyze cerebrospinal fluid metabolites.
• Screening differential metabolites, metabolic pathway analysis, discover new biomarkers and other non-targeted metabolomics analysis.

Flow Chart of Animal Non-targeted Metabolomics Analysis Service

Metabolomics-Based Animal Neuroscience Solutions

• Neurological Disease Diagnosis and Monitoring

Most neurological diseases in animals are accompanied by severe neuronal damage and are not easily diagnosed in the early stages. Current treatments can only slow the progression of the disease and cannot reverse nerve damage. By providing metabolomic analysis of cerebrospinal fluid, we identify specific biomarkers that can facilitate efficient and reliable diagnosis of neurological diseases in animals. This aids in conducting valuable scientific research projects, preventing disease progression, and implementing effective treatments. Metabolomics research is rapidly advancing our understanding of the mechanisms of neurological diseases in animals.

• Brain Biomarker and Therapy

Biomarkers can help diagnose brain diseases or monitor physiological changes in the nervous system of animals. Our animal cerebrospinal fluid metabolomic analysis can detect hundreds of metabolites using techniques such as GC-MS, NMR, and LC-MS. In addition, we have developed extensive metabolite databases and sophisticated analysis algorithms. By establishing a strong link between metabolomics and disease prediction, therapy development, and health status assessment, cerebrospinal fluid metabolomics is proving to be a powerful tool for advancing research programs in the field of animal neurology. This is achieved by analyzing markers associated with neurological diseases and physiological states in animals.

Why Choose Us?

BioVenic offers a comprehensive suite of services for isolating, characterizing, identifying, and validating cerebrospinal fluid metabolomic analysis. These services are customized to provide accurate and precise results, while maintaining excellent robustness and reproducibility. Through advanced high-throughput technology platforms such as NMR, HPLC-UV, LC-MS, GC-MS, and ICP-MS, we offer reliable, high-quality, and efficient CSF non-targeted metabolomics customized services for those scientific research topics that investigate the metabolic state of the central nervous system, physiological health, and the development of biomarkers associated with neurological diseases and neurodegenerative diseases. Get in touch with us and experience the wonders of animal metabolomics research!

Reference

1. Bohnert, Simone, et al. "Metabolomics in postmortem cerebrospinal fluid diagnostics: a state-of-the-art method to interpret central nervous system–related pathological processes." International Journal of Legal Medicine 135 (2021): 183-191.