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Veterinary Therapeutic Antibody Manufacturing
BioVenic offers veterinary therapeutic antibody manufacturing services, encompassing the entire process. Whether the immunogens needed for animal immunization or gene-engineered antibodies expressed using gene sequences in systems, we have established corresponding development platforms to offer a variety of choices. Throughout the process, we apply strict and reliable quality control aiming to deliver tailored, efficient, and high-quality veterinary therapeutic antibodies to meet various experimental and research needs.
Antigen Preparation
BioVenic offers antigen preparation services. We cover a wide range of antigen types, and we guarantee that the final product has very high purity and extremely low levels of endotoxin residue, ensuring the generation of high-quality, specific antibodies.
| Proteins | Peptides | DNA | mRNA | VLPs |
Antibody Production
By employing recombinant DNA technology, the modified antibody gene sequences are constructed into plasmids. Subsequently, using protein expression technology, these engineered plasmids are transfected/transformed into suitable host cells for the expression of monoclonal antibodies. BioVenic has established various expression systems for veterinary therapeutic antibody manufacturing, such as the bacterial expression system, yeast expression system, and mammalian cell expression system. We offer a one-stop service, including gene synthesis, antibody expression, purification, and subsequent quality control. This ensures the delivery of veterinary therapeutic antibodies with high purity and low endotoxin levels.
Fig.1 Antibody development workflow. (BioVenic Original)
Quality Control
BioVenic upholds stringent quality control procedures to guarantee that the supplied antibodies conform to superior quality benchmarks, using numerous testing and analysis methods.
- Cell Identification
Ensuring the manufacturing of qualified recombinant antibodies relies on having qualified production cells as a prerequisite and foundation. BioVenic provides comprehensive testing on production cells to guarantee the safety and efficacy of veterinary therapeutic antibodies. This includes performing cell identification tests to confirm the species origin of the cells and to eliminate the possibility of cross-contamination from other cells.
| Cell Morphology Identification |
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|---|---|
| Biochemical Assays |
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| Genetic Assays |
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| Genetic Marker Assays |
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- Pathogenic Microorganism Detection
BioVenic provides pathogenic microorganism detection for veterinary therapeutic antibody-manufacturing cells. For the sterility test of cell culture supernatant, we use culture media that are suitable for the growth of aerobic bacteria, anaerobic bacteria, and fungi, ensuring that the sensitivity of the media meets the required standards. For viruses, we offer testing methods to determine whether there are any potentially infectious viruses present in the cells to be tested, as well as in their lysates or harvest fluids. The types of viruses and methods of testing are determined based on the species origin and characteristics of the cells.
| Sterility Checks on Cell Culture Supernatants |
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|---|---|
| Internal and External Virus Detection |
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- Impurity Analysis
The purity determination is a critical testing indicator for veterinary therapeutic antibodies, directly reflecting whether the effective separation of the antibody molecules and impurities has been achieved. BioVenic offers impurity analysis services for veterinary therapeutic antibodies, employing numerous methods to determine the purity of your samples. Veterinary therapeutic antibodies exhibit charge differences due to amino acid modifications (such as deamidation, oxidation, glycosylation.) or cleavage. BioVenic provides antibody charge heterogeneity analysis to help distinguish between the original antibody and its degradation products or modified forms, enabling a more comprehensive understanding and control of the quality of veterinary therapeutic antibody manufacturing.
| Purity Analysis | CE-SDS, SDS-PAGE, SEC, RP, LC, LC/MS, GC, GC/MS, SFC. |
|---|---|
| Charge Heterogeneity Analysis | IEF, CEX, CIEF, iCIEF. |
- Stability Testing
Veterinary therapeutic antibodies with excellent stability have the ability to ensure the preservation of their activity during manufacturing and purification processes, as well as maintain the drug's effectiveness during long-term storage, cold chain transportation, and usage at room temperature. BioVenic provides veterinary therapeutic antibody stability testing services, assisting you in selecting candidates with high safety and extended efficacy.
| Physicochemical Property Testing | Appearance, pH value. |
|---|---|
| Potency assay | ELISA |
| Thermal stability testing | DSC |
| Solubility testing | CIC, AC-SINS, CSI-BLI. |
Why Choose Us?
Covering most types of antigens for animal immunization.
A wide range of antibody expression systems to meet specific veterinary therapeutic antibody development needs.
High veterinary therapeutic antibody quality and purity for fast and flexible delivery.
Powerful and diversified detection and analysis technologies provide you with strict quality control.
With advanced technology and many professionals, BioVenic is committed to providing the services of veterinary therapeutic antibody manufacturing. From antibody preparation to production, including the formulation of immunization strategies, immunogen preparation, antibody production, and purification, our services cover the whole process, utilizing wide-ranging detection and analysis to assist you in developing safe and effective veterinary therapeutic antibodies from lab-scale to large-scale. If you are interested in veterinary therapeutic antibody manufacturing, please contact us now!