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Antimicrobial Resistance (AMR) in Animal-Specific Pathogens
Antimicrobial resistance is developing as a growing concern due to the overuse and misuse of antimicrobials in veterinary practice and agriculture. As a Contract Research Organization (CRO) specializing in AMR research for animal-specific pathogens, BioVenic is dedicated to advancing the understanding, detection, and treatment development of Antimicrobial Resistance (AMR) to ensure the well-being of animals and safeguard public health. Our comprehensive suite of services contains antimicrobial resistance (AMR) genetics and genomics, phenotypic resistance characterization, pharmacokinetics/pharmacodynamics (PK/PD) studies, and mechanism investigations into animal-specific pathogen resistance and pathogenesis.
Antimicrobial Resistance (AMR) Services for Animal-Specific Pathogens
As a leading CRO in the field of veterinary research, we offer a range of services designed to address the complexities of AMR in animal-specific infectious bacterial and fungus. Our multidisciplinary team comprises experts in microbiology, veterinary medicine, molecular biology, and bioinformatics, all working collaboratively to provide high-quality, customized research solutions.
Animal-Specific Pathogen Identification and Characterization
Accurate identification and characterization of animal-specific pathogens are crucial for understanding the epidemiology of veterinary AMR. We employ advanced morphology and molecular techniques to identify and characterize a wide variety of animal pathogens. Our capabilities include but are not limited to the followings.
- Veterinary AMR Genotypic Characterization
- Veterinary AMR Gene Discovery
- Veterinary Pathogen Antimicrobial Resistance Phenotypic Characterization
Antimicrobial Susceptibility Testing
We provide a wide range of antimicrobial susceptibility testing (AST) services for animal specific pathogens and antimicrobial drug candidates to develop effective treatment strategies for animals, it is essential to determine the susceptibility of pathogens to various antimicrobials. Our services cover from classic dilution and diffusion tests to molecular-based methods and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS) service.
| Classic Methods | Molecular-Based Methods | Mass Spectrometry |
|
Dilution Disk Diffusion Test Antimicrobial Gradient Method Chromogenic Agar Media Colourimetric Test |
PCR qPCR DNA-Microarrays WGS |
MALDI-TOF MS |
Animal-Specific Pathogen PK/PD Services
We offer comprehensive PK/PD services tailored specifically for animal pathogens and treatment candidates, leveraging our expertise in veterinary pharmacology and microbiology. Our services encompass the entire spectrum of PK/PD studies, from initial drug screening to advanced in vitro, in vivo, ex vivo, and mathematic modeling and simulation for effective drug screening and validation and for optimizing dosing regimens.
Animal-Specific Pathogen Mechanism Studies
The mechanisms underlying animal-specific pathogen drug resistance and animal pathology is essential for developing novel treatment for animals. Custom mechanism studies help identify genetic, biochemical, and physiological factors contributing to resistance, guiding the development of new drugs and treatment strategies for animals. Our approach combines cutting-edge technologies with deep biological and molecular insights to provide comprehensive mechanism studies.
Fig.2 General antimicrobial resistance mechanisms.
Our Advantages
- We offer tailored one-stop research solutions to meet animal-specific pathogen AMR research needs, providing flexibility in project design and execution.
- We utilize classic and advanced technologies to provide comprehensive insights into antimicrobial resistance, driving the development of effective treatment strategies for animals.
- We offer customized research services to meet the unique needs of each client, addressing specific challenges posed by various animal pathogens.
- Our services focus on multiple animal species types, including food animals, companion animals, monogastric animals, ruminants, aquatic species.
| Common Animal-Specific Pathogens | ||
| Species | Pathogen | Resistance |
| Dogs and Cats | Campylobacter jejuni | Aminoglycosides, Fluoroquinolones, Lincosamides, Macrolides, Tetracycline, Multidrug Resistance |
| Enterobacteriaceae and Acinetobacter spp. | Penicillins, Cephalosporins, Fluoroquinolones | |
| Enterococcus spp. | Penicillins, Fluoroquinolones, Macrolides | |
| Pseudomonas aeruginosa | Fluoroquinolones, Carbapenems | |
| Staphylococcus spp. | Cephalosporins, Fluoroquinolones, Lincosamides, Macrolides, Penicillins, Tetracyclines | |
| Equine | Enterobacteriaceae | Penicillins, Extended-spectrum beta-lactamase (ESBL) |
| Pseudomonas aeruginosa | Macrolides, Penicillins, Tetracyclines, Fluroquinolones | |
| Staphylococcus spp. | Multidrug Resistance, Methicillin, Macrolides, Tetracyclines, Fluoroquinolones. | |
| Swine | Escherichia coli | Ceftiofur, Enrofloxacin, Florfenicol, Gentamicin, Neomycin, Sulfonamides, Tetracyclines |
| Pasteurellaceae | Tetracyclines, Enrofloxacin, Tiamulin | |
| Salmonella | Tetracyclines , Aminoglycosides, Sulfonamides, Beta Lactams, Macrolides, Phenicols, Pleuromutilins, Cephalosporins, Fluoroquinolones | |
| Streptococcus suis | Beta lactams, Ceftiofur, Enrofloxacin | |
| Cattel | Mannheimia haemolytica and Histophilus somni | Multidrug Resistance, Aminocyclitols, Fluoroquinolones, Phenicols, Penicillins, Tetracyclines, Macrolides |
| Moraxella spp. | Tetracyclines, Macrolides | |
| Sheep and Goats | Campylobacter jejuni | Tetracyclines |
| Staphylococcus spp. | Beta-lactams, Macrolides | |
| Poultry | Escherichia coli | Tetracyclines, Sulfonamides, Streptomycin |
| Ornithobacterium rhinotracheale (ORT) | Tetracyclines, Sulfonamides, Penicillin | |
| Pasteurella multocida | Tetracyclines, Sulfonamides, Penicillin | |
| Aquatic Species | Aeromonas spp. | Oxytetracycline, Florfenicol, Ormetoprim/sulfadimethoxine |
| Edwardsiella spp. | Oxytetracycline, Florfenicol, Ormetoprim/sulfadimethoxine | |
| Flavobacterium psychrophilum | Multidrug Resistance, Oxytetracycline, Florfenicol, Ormetoprim/sulfadimethoxine | |
| Vibrio parahaemolyticus | Beta-lactams, Tetracycline, Cephalosporins, Chloramphenicol, Aminoglycosides, Fluoroquinolones, Sulfonamides, Macrolides, Rifampin, Trimethoprim, Fosfomycin, Bicozamycin | |
| Vibrio vulnificus | Apramycin, Nalidixic acid, Azithromycin, Chloramphenicol, Ampicillin, Doxycycline, Tetracycline | |
BioVenic is committed to advancing the understanding and management of AMR in animal-specific pathogens through phenotypic assays, molecular assays, cutting-edge PK/PD, and mechanism studies. Our comprehensive services, tailored to the unique challenges of veterinary pathogens, provide valuable insights that drive the development of effective antimicrobial therapies and strategies. For more information about our animal-specific pathogen antimicrobial resistance research and development solution, please don't hesitate to contact us.