Veterinary Bacterial Antimicrobial Resistance (AMR) Solutions

The emergence of multi-drug resistant (MDR), extensively-drug resistant (XDR), and pan-drug resistant (PDR) strains exacerbates this problem, leading to infections that are increasingly difficult to treat. Addressing AMR requires in-depth research and innovative solutions, which is where BioVenic's specialized services come into play. Our advanced capabilities include bacterial AMR genetics and genomics services, phenotypic resistance characterization, and pharmacokinetic/pharmacodynamic (PK/PD) studies, ensuring a holistic approach to understanding bacterial resistance.

Veterinary Bacterial Antimicrobial Resistance (AMR) Services

We are dedicated to offering a wide range of specialized services tailored to the unique challenges of veterinary AMR. Studying veterinary bacterial antimicrobial resistance requires a multifaceted approach that encompasses genotypic and phenotypic characterization, susceptibility testing, PK/PD testing, and other strategic analysis. BioVenic offers a wide range of antimicrobial resistance testing and analysis services aimed at tackling veterinary bacterial AMR.

Veterinary Bacterial AMR Genomic Characterization

Understanding the genetic mechanisms underlying bacterial resistance is crucial for developing effective interventions. We provide comprehensive bacterial genomic identification and characterization services, including bacterial pathogen targeted and untargeted genomic sequencing and customized bioinformatic analysis, providing detailed insights into resistance genes, mutations, and evolutionary trends. We also conduct metagenomic studies to explore the genetic material within microbial communities, identifying potential reservoirs and transmission routes of resistance genes. Our bioinformatics team uses cutting-edge tools to interpret complex genetic data, while gene expression studies reveal how bacteria regulate resistance mechanisms under various conditions.

Veterinary Bacterial AMR Phenotypic Characterization

Phenotypic characterization is essential for directly assessing bacterial resistance traits. Our phenotypic resistance characterization services include Antibiotic Susceptibility Testing (AST) using methods like broth microdilution, disk diffusion, and E-test to determine the Minimum Inhibitory Concentrations (MICs) of antibiotics against specific bacterial isolates. We identify resistance mechanisms through biochemical assays and molecular techniques, providing a thorough understanding of how bacteria evade antibiotics. Synergy testing evaluates the effectiveness of antibiotic combinations, which is crucial for developing treatment regimens that can overcome resistance. Additionally, our time-kill studies assess the dynamics of bacterial killing and regrowth over time, offering valuable data on the bactericidal activity of antibiotics.

Veterinary Bacterial AMR PK/PD Services

Understanding the relationship between drug concentrations, bacterial kill rates, and resistance suppression is critical for optimizing antibiotic therapy. Our pharmacokinetic and pharmacodynamic (PK/PD) services involve pharmacokinetic studies, pharmacodynamic studies, PK/PD mathematical model construction, as well as in vitro, in vivo, and ex vivo PK/PD modeling. Our services aim to help define optimal dosing regimens, evaluate the effects of antibiotics on bacteria, maximize efficacy of antibiotics research and development for animals.

Veterinary Bacterial AMR Mechanism Studies

Investigating the mechanisms of AMR is key to developing targeted interventions. Our veterinary bacterial AMR mechanism studies delve into the biochemical and genetic underpinnings of resistance. We use molecular techniques to identify and characterize resistance mechanisms such as beta-lactamase production, efflux pump activity, and target site modifications. By understanding these mechanisms, we can develop new therapeutic approaches and improve existing ones. Our services also explore the interactions between different resistance mechanisms, offering a comprehensive view of how bacteria adapt to survive antibiotic treatment.

Fig.2 General antimicrobial resistance mechanisms.

Our Advantages

• Our team of highly skilled scientists brings extensive experience in veterinary microbiology, genomics, pharmacology, and bioinformatics.
• We utilize the advanced technologies and methodologies for AMR studies to deliver accurate, reliable, and actionable data for bacterial pathogens.
• Our services are tailored to meet the specific veterinary AMR research and development needs of our clients, ensuring that every project receives the attention and expertise it deserves.

BioVenic committed to advancing the fight against veterinary bacterial antimicrobial resistance. Our comprehensive services, from bacterial AMR genetics and genomics to phenotypic resistance characterization, PK/PD studies, and AMR mechanism studies, provide the insights and solutions needed to tackle MDR, XDR, and PDR in animals. For more information about our services for veterinary AMR research and development, please don't hesitate to contact us.