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Toxoid Veterinary Vaccine Development
Toxoid veterinary vaccines are a type of vaccine used to prevent diseases in animals caused by toxin-producing bacteria. Its preparation process involves inactivating toxic portions of the toxin produced by bacteria pathogens, which is then used as a component of vaccines to stimulate a protective immune response in the animal organism. BioVenic provides veterinary toxoid vaccine development for you to help animals fight bacterial pathogens.
Our Services
The following diagram shows a brief toxoid veterinary vaccine development process. BioVenic provides a full range of services to assist you in veterinary development.
Bacteria Culture
BioVenic provides services starting with bacteria culture for subsequent extraction of the toxin required for veterinary vaccine development. We inoculate the pathogens into media containing appropriate nutrients. BioVenic provides customized bacterial media according to your needs by adjusting its formula components to meet your needs for pathogen cultivation and providing the appropriate temperature, humidity, and atmosphere to promote growth during the cultivation process to maintain an optimal environment for the growth of pathogens.
Toxin Detoxification
To ensure the safety of your vaccine, BioVenic offers toxin detoxification services. The process includes extracting the target toxin from pathogen cultures, removing bacterial cells and other impurities through centrifugation and filtration, and subsequently detoxifying the extracted toxin using formaldehyde. BioVenic also provides detoxification validation services by inoculating the toxin into animals and observing their reactions, as well as mass spectrometry and high-performance liquid chromatography to analyze the structure and composition of detoxified toxins, and any specific structures associated with toxicity should be identified and validated for detoxification.
Toxin Purification
Purification of detoxified toxins is usually similar to conventional toxin purification methods, but the process requires attention to ensure that the toxin has been detoxified for toxicity. BioVenic offers purification services for your toxoid veterinary vaccines after the toxin has been detoxified to ensure the quality of your veterinary vaccines.
| Purification Services | Description |
|---|---|
| Ion Exchange Chromatography | Target toxins can be eluted stepwise by adjusting the salt concentration and pH, different ion exchange resin choices and gradient conditions are used to separate different protein fractions. |
| Affinity Chromatography | By employing affinity column chromatography, such as affinity resins containing ligands, specific capture of the target toxin is achieved, followed by purification of the target toxin through elution. |
| Gel Filtration Chromatography | Target toxins can be separated according to their molecular size. |
| High Performance Liquid Chromatography | HPLC provides high-resolution and efficient separation and is used to remove minute impurities. |
Formulation Development
Currently commercially produced vaccines consist of a combination of inactivated natural toxins (toxoids) and conventional adjuvants. BioVenic provides formulation development services to select the most suitable adjuvant formulation for toxoids through well-designed experimental content to enhance the overall immunogenicity of your toxoid veterinary vaccines. BioVenic also provides safety assessment services to prevent the added adjuvant components from causing adverse reactions to the vaccinated animals and any negative impact on animal health.
Toxoid Veterinary Vaccine Development Services
BioVenic provides high-quality animal models and carefully designed experimental protocols to assist you in toxoid veterinary vaccine development.
Epidemiological studies have proved that the toxoid veterinary vaccine is a safe and effective vaccine for preventing disease epidemics, and its quality control inspections mainly include identification tests, physical and chemical inspections, determination of antigenic content, purity determination, etc., to ensure the quality of the products in terms of safety, purity, and efficacy.
Due to the possibility of toxin reversal under certain conditions, in addition to standard aseptic safety checks, BioVenic also offers unique safety assessment procedures, including specific toxicity assessments and toxicity reversal tests. We help establish toxin-sensitive animal models to assess the complete detoxification and stability of the toxoid.
Toxin impurity residue checks primarily involve determining the residual formaldehyde levels of the detoxifier, conducted using conventional calibration methods.
Why Choose Us?
BioVenic boasts high-quality bacterial cultivation facilities and customized culture media supply.
With extensive detoxification expertise, BioVenic provides validation services to ensure you receive reliable results.
Our advanced purification equipment and a diverse range of purification methods empower you to attain top-quality toxoids during development.
Toxoid veterinary vaccines represent a historically significant and effective vaccine category. It retains the property that an animal's exposure to a toxin induces antibody formation. BioVenic provides the mentioned services, aiding numerous researchers in accomplishing vaccine development projects for livestock, poultry, companion animals, aquaculture species and more. Contact us now and let's embark on the path of your veterinary vaccine development together!