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Veterinary Therapeutic Antibody Discovery
Veterinary therapeutic antibodies improve animals' life quality and health. BioVenic offers the full service for veterinary therapeutic antibody discovery, assisting in developing and screening antibodies for treating animal diseases. Our antibody discovery services include screening antibodies from various antigen sources, such as pathogens or biomarkers, followed by further optimization and evaluation to identify promising therapeutic candidates.
Fig.1 Three platforms for therapeutic antibody preparation.1,2
Target Screening
Target screening is a crucial step in veterinary therapeutic antibody development, helping identify the most suitable molecules or cellular structures as the optimal targets for therapy. BioVenic utilizes a variety of emerging technologies for veterinary therapeutic antibody target screening services, ensuring that chosen targets exhibit high specificity and biological significance.
| Services | Description | Procedure |
|---|---|---|
| CRISPR Library Screening | Combining CRISPR-Cas9 gene editing technology and high-throughput screening methods. A large number of genes are simultaneously interfered with or knocked out in a cell or organism to identify the function of a specific gene. |
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| siRNA Library Screening | siRNA can be targeted to inhibit or reduce the expression of specific genes. siRNA molecules are introduced to silence or reduce the expression of target genes on a target-by-target basis to understand their functions. |
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| NGS single-cell sequencing | Ability to study the different biological properties of individual cells in complex tissues and to understand different cell subpopulations and their biological functions. |
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Antibody Preparation
BioVenic has established multiple platforms for antibody preparation in veterinary therapeutic antibody discovery. Our platforms include hybridoma, phage display, and single B technology, addressing the unique challenges of veterinary therapeutic antibody discovery.
| Platforms | Advantages | Limitations |
|---|---|---|
| Hybridoma Platform |
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| Single B Cell Platform |
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| Phage Display Platform |
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Antibody Characterization
BioVenic offers structural and functional characterization services for the initial screened veterinary therapeutic antibody samples obtained in the preparation. From the multi-level structure of the protein to antigen and antibody interaction, BioVenic provides various analytical methods to offer relevant information, aiding in the selection of suitable candidates for veterinary therapeutic antibodies with the desired treatment effects.
| Services | Targets | Methods |
|---|---|---|
| Structural Characterization | Primary Structure |
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| Secondary and Higher-Order Structures |
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| Post-Translational Modification |
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| Functional Characterization | Antigen-antibody Interaction |
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| Cellular Function |
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Antibody Engineering
Reducing its immunogenicity in animals and enhancing its effectiveness are key issues that need to be addressed for veterinary therapeutic antibodies. BioVenic provides antibody engineering services to address these concerns. Through our antibody caninization and felinization services, veterinary therapeutic antibodies have lower immunogenicity. And our antigen affinity maturation services avoid a potential decrease in antigen affinity during caninization and felinization. We also provide Fc engineering modification services, extending veterinary therapeutic antibody half-life.
Why Choose Us?
State-of-the-art technology and equipment, high-quality animal models, and professional staff enhance the success rate of your project.
A full-service platform to facilitate the veterinary therapeutic antibody discovery process.
Multiple assays and detection methods to provide you with a more personalized experience.
The process of discovering veterinary therapeutic antibodies is complex and diverse, given the intricacies of their structures and functions. With involvement in numerous antibody discovery projects and extensive experience, BioVenic offers a comprehensive range of veterinary therapeutic antibody discovery services to accelerate the progression of veterinary therapeutic antibody development. If you're interested in our services, contact us now!
Reference
- Zhang, Zaibao, et al. "Advances in the isolation of specific monoclonal rabbit antibodies." Frontiers in Immunology 8 (2017): 494.
- Image retrieved from Figure 1 "Flowchart summarizing the generation of antigen-specific monoclonal antibodies", Zhang, Zaibao, et al., 2017, used under [CC BY 4.0], the image title was changed to "Three platforms for therapeutic antibody preparation."