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Animal Epigenomics Solutions
Background
BioVenic has introduced a comprehensive range of customized solutions and one-stop services for animal epigenetics. These solutions involve the analysis of biological information using various epigenetic mechanisms, including DNA methylation and the modifications of histone and chromosome structures. We are dedicated to offering technical support and program design for researchers investigating the relationship between epigenetic mechanisms and animal diseases, productivity, and other traits. Our goal is to elucidate the impact of animal epigenomics on growth and development from a multi-omics perspective.
Background
Animal epigenetics is the study of heritable phenotypic changes that alter genetic material or related proteins without involving changes in the nucleotide sequence. Transcription, translation, and subsequent protein modification enable animal cells with identical DNA sequences to generate different cell types and functions. The various types of regulation involved in animal epigenomics are crucial for animal development, traits expression, and animal disease mechanism studies.
Fig.1 Schematic Diagram of Animal Epigenome Modifications. 1
Animal Epigenomics Analysis Services
BioVenic offers the one-stop solution for animal epigenomics sequencing and analysis, making it a dependable option for comprehending epigenetic mechanisms and analyzing epigenomic data. This includes the identification, annotation, and analysis of signals or genomic regions of interest. We offer efficient, focused, and expert solutions for various epigenomic modification mechanisms.
BioVenic offers comprehensive and reliable customized services for global scientific researchers, including methylation status, enrichment, and sequencing analysis of animal DNA and RNA. These solutions cover single base as well as whole-genome methylation levels. Our team specializes in localizing methylation regions, quantifying methylation levels, and conducting differential methylation analysis to assist customers in addressing a range of challenges encountered in related research.
BioVenic offers a comprehensive range of customized services for analyzing histone modifications in animal epigenetics to meet the specific needs of users. We study regulatory elements, interacting promoters, and enhancers for our clients, and quantify histone modifications across the genome. We utilize ChIP detection, Seq, and high-throughput MS platforms to achieve full coverage of various histone modifications and to decode the biological information embedded in animal epigenetic regulation.
BioVenic has developed standardized operating procedures for analyzing animal chromatin-related modifications and three-dimensional states. These procedures support customers in studying animal epigenetics from the perspective of chromatin structure, enabling analysis of its regulatory mechanisms related to individual development and diseases.
BioVenic offers personalized sequencing and analysis services for non-coding RNAs (ncRNAs) in animals, which play a role in regulating gene expression and chromatin remodeling. Through in-depth research on ncRNA, our expert team enables customers to analyze a range of crucial biological functions, including their impact on the regulation of fundamental life processes, economic traits, and animal welfare.
Animal Epigenomics Analysis Platforms
BioVenic employs a range of animal epigenomics research strategies to investigate the diverse modifications that impact animal biological activities. Our dedication to thorough reliability is evident in the scope of our epigenetic analysis platform. Please refer to the links in the table to learn more about our sequencing analysis technology platforms.
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Whole Genome Bisulfite Sequencing (WGBS) BioVenic provides Whole Genome Bisulfite Sequencing (WGBS), the platform that involves the conversion of sequences using sodium bisulfite and high-throughput DNA sequencing. This allows users to analyze DNA methylation at single-base resolution. |
Representation Bisulfite Sequencing (RRBS) Reduced Representation Bisulfite Sequencing (RRBS) platform effectively covers almost all promoters, CpG islands, repetitive DNA sequences, and regulatory elements in samples. We employ a combination of sequencing, bisulfite treatment, and restriction enzymes to analyze genomic regions with high CpG content, reducing the experimental volume and enhancing the efficiency of sample utilization. |
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Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) BioVenic identifies and analyzes the location of N6-methyladenosine (m6A) in animal RNA samples using methylated RNA immunoprecipitation sequencing (MeRIP-seq). This platform identifies and characterizes modified bases in RNA by localizing antibodies to m6A. |
Chromatin Immunoprecipitation Sequencing (ChIP-seq) BioVenic's Chromatin Immunoprecipitation Sequencing (ChIP-Seq) platform is tailored for scientific users who need comprehensive analysis of histone modifications and their interactions with genes. The platform combines ChIP assays with next-generation sequencing to accurately map genome-wide histone modifications, such as methylation, acetylation, phosphorylation, and ubiquitination. |
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Assay for Transposase-Accessible Chromatin with Sequencing (ATAC-seq) Based on Assay for Transposase-Accessible Chromatin with Sequencing (ATAC-seq), our technical team utilizes the highly active Tn5 transposase to insert sequencing adapters into open regions of chromatin. Subsequently, we analyze the sequencing data to deduce the accessibility of chromatin regions in animal samples. |
CRISPR-based Chromatin Affinity Purification with Mass Spectrometry (CRISPR-ChAP-MS) BioVenic utilizes the advanced protein-DNA interaction research platform that is based on CRISPR chromatin affinity purification and mass spectrometry. This platform enables customers to accurately visualize the dynamic changes and functional information of complexes at specific chromatin sites. |
Why Choose Us?
BioVenic offers a comprehensive range of animal epigenomics solutions to meet the needs of sample sequencing and analysis across multiple species.
BioVenic provides highly customized solutions for its customer base. Our expert team designs projects tailored to address your specific challenges or areas of interest in animal epigenetics.
BioVenic has established a diverse epigenetic sequencing data analysis platform, leveraging multidisciplinary fields to conduct comprehensive and professional bioinformatics analysis in depth.
Our bioinformatics analysis encompasses all facets of animal epigenome research, such as chromatin, methylation, histone, differential analysis, transcription factor binding sites, and multi-omics analysis.
BioVenic specializes in cutting-edge technologies in the field of animal epigenomics, including whole-genome next-generation sequencing, dynamic imaging of genomic loci, quantitative proteomics, and advanced data analysis software. Our multidisciplinary team of experts develops the most practical, reliable, and efficient solutions tailored to the specific needs of the animal research project and offers technical support throughout the process. Multiple quality controls and extensive experience ensure stable and accurate report output to meet your animal epigenomics research requirements. Please feel free to contact us for a quotation.
References
- Kim, Do-Young, and Jun-Mo Kim. "Multi-omics integration strategies for animal epigenetic studies—A review." Animal Bioscience 34.8 (2021): 1271.
- Triantaphyllopoulos, Kostas A., Ioannis Ikonomopoulos, and Andrew J. Bannister. "Epigenetics and inheritance of phenotype variation in livestock." Epigenetics & chromatin 9.1 (2016): 1-18.