Veterinary Organoid Therapy Development

Organoid-related technology has demonstrated significant potential and advantages in the development of companion animal therapeutics and the evaluation of veterinary drugs. Organoids are three-dimensional biological models created by extracting cells from animal tissues and culturing them in vitro. They can effectively simulate the structure and function of organs as well as the spatial environment of each cell in multiple dimensions. BioVenic remains committed to the advancement of organoid-related technology for the treatment of animal diseases and the establishment of in vitro research models, and offers scientific researchers a comprehensive range of customized solutions for the development of veterinary organoid therapies. The use of organoids in therapeutic development and pharmacological research not only shortens the therapeutic development cycle, but also improves the accuracy of efficacy predictions. Due to their high physiological relevance, organoids provide a streamlined pathway for translating companion animal therapeutics from the laboratory to the clinic, laying the foundation for personalized treatment and precision medicine for companion animals.

Fig.1 Development Direction of Organoid-related Technology in Veterinary Medicine.^1,2

Veterinary Organoid Development and Establishment

BioVenic develops and establishes organoid models for specific diseases to study disease pathways and pharmacological responses. Our personalized customization services ensure that the models mimic the physiological characteristics of the target animals as closely as possible. Our advanced 3D organoid culture technology has established mature technical processes and quality control systems to ensure high reproducibility and stability.

Gene Editing of Veterinary Organoids

BioVenic supports gene editing research using organoid models to investigate the potential of gene therapy to treat specific animal diseases and to identify additional gene targets associated with these diseases. Our advanced CRISPR/Cas9 and other gene editing technologies enable efficient and precise modifications, allowing us to specifically study the efficacy of gene mutations in various animal diseases.

Drug Screening and Toxicology Testing Using Organoids

In the field of companion animal therapeutics and pharmacology, BioVenic offers clients innovative solutions for new drug screening and toxicology testing using organoid models to assess drug efficacy and safety. We use organoids for high throughput screening, enabling the evaluation of a significant number of drug candidates and providing accurate non-GLP toxicology analyses in a short timeframe, thereby enhancing the scientific rigor of experimental results.

3D Animal Cell Culture System Development

3D cell culture provides an exceptional technical platform for the development of companion animal therapeutics and the evaluation of veterinary drugs by enabling the reconstruction of the spatial arrangement of animal cells in vitro. These 3D cell culture systems have attracted increasing attention due to their significant advantages over traditional 2D cell culture systems in providing more physiologically relevant information and predictive data. To meet the needs of researchers for organoid development technology, BioVenic provides advanced services for 3D animal cell culture, including the development of scaffold systems and serum-free culture systems.

Fig.2 Schematic Diagram of 3D and 2D Animal Cell Culture Status.

Applications of Organoids in Companion Animal Disease Research

Why Choose Us?

Combined with the ongoing advancements in scientific research technology, BioVenic's veterinary organoid development services address the needs of the veterinary community and are dedicated to advancing the research and development of animal diseases. Using state-of-the-art technologies such as organoid culture, BioVenic aims to provide innovative, precise, and ethical solutions to researchers in the field of companion animal therapeutics development. This support assists them at critical stages of veterinary drug development and animal disease research. Through the comprehensive services mentioned above, BioVenic not only meets the individual needs of its clients but also ensures that each research project progresses smoothly, leading to significant advances in the development of veterinary organoid therapies. If you are considering integrating organoids into your experimental plan, please do not hesitate to contact us for further discussion.

References

1. Image retrieved from Figure 1 "Potential and current applications of organoids in veterinary medicine." Penning and Robin, 2023, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to " Development Direction of Organoid-related Technology in Veterinary Medicine."
2. Penning, Louis C., and Robin van den Boom. "Companion animal organoid. technology to advance veterinary regenerative medicine." Frontiers in Veterinary Science 10 (2023): 1032835.