Animal Mesenchymal Stem Cell Paracrine Analysis

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Animal Mesenchymal Stem Cell Paracrine Analysis

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Paracrine Regulation of Animal MSCs Paracrine Composition Analysis of Animal MSCs Paracrine Protein Identification and Characterization MSC Secretome Key Components Why Choose Us?

Animal mesenchymal stem cells (MSCs) have always been a research hotspot in tissue engineering and veterinary regeneration. They have been widely used as ideal seed cells to repair and reconstruct animal tissues and organs affected by aging, disease, and injury. MSCs have a relatively wide range of sources and diverse functions. They actively secrete cytokines and growth factors through important paracrine functions to act on neighboring cells, regulating the immune system, inflammatory responses, and stimulating neovascularization. BioVenic provides detailed and professional analysis services related to the paracrine effects of MSCs to global scientific researchers. These services include secretion regulation, secretome composition, and expression analysis. Our expert team strongly supports researchers in projects related to the use of the secretome to regulate and treat physiological processes.

Fig.1 EV-mediated paracrine action of MSCs in angiogenesis. (Maacha, et al., 2020) Fig.1 MSCs Promote New Blood Vessel Formation in A Paracrine Manner.^1,2

Paracrine Regulation of Animal MSCs

BioVenic offers personalized solutions that use various technical methods and external stimuli to increase the overall paracrine level of MSCs. At the same time, for clients interested only in specific components or cytokines, our experts and technical staff will determine the most feasible and appropriate service content based on the experience and professional knowledge accumulated in previous projects.

Inducing physiological stress	Using external signals
Modulating cell-matrix interactions	Enhancing cell-cell interactions

Paracrine Composition Analysis of Animal MSCs

BioVenic offers compositional analysis and secretion level assessment for the complex paracrine group of MSCs. We integrate the omics analysis platform with multiplex immunoassay analysis to dissect and quantify the paracrine network and capture the detailed biological information it contains thoroughly and accurately.

Paracrine Protein Identification and Characterization in Animal MSCs

The main characteristic functions of the paracrine proteome of animal MSCs include anti-inflammation, promotion of angiogenesis, and immune regulation. Some also exhibit activities such as anti-fibrosis, neuroprotection, and promotion of cell proliferation. BioVenic explores and determines the significant biological functions performed by the MSC secretome of MSCs from different sources by identifying and characterizing secreted proteins and cytokines.

Fig.2 Cytokines Involved in Paracrine Effects of MSCs. (BioVenic Original) Fig.2 Typical Cytokines Involved in Paracrine Effects of MSCs.

MSC Secretome Key Components

Cytokines	Functions
EGF	Regulates glycolysis, protein phosphorylation, and cellular calcium metabolism. Induces the secretion of VEGF, IL-8, and EGR-1 expression. Promotes cell proliferation, epidermal regeneration, and blood vessel formation. Stimulates epidermal cells to synthesize and secrete hyaluronic acid and promotes the growth of connective tissue cells. Activates the epidermal growth factor receptor signaling pathway to influence cell proliferation, apoptosis, and migration.
HGF	Promotes angiogenesis and nerve regeneration. Promotes cell invasion and migration and resists apoptosis. Prevents fibrosis and regulates cardiomyocyte autophagy.
TGF‐β	Promotes the synthesis of protease inhibitors. Upregulates cell adhesion molecules and inhibits the synthesis of matrix proteases. Regulates fibroblast activity. Promotes wound healing and prevents fibrosis of repairing tendons. Promotes chondrocyte proliferation, adhesion, and differentiation.
KGF	Promotes proliferation, differentiation, and migration of various tissue cells. Promotes cell mitosis and resists apoptosis.
bFGF	Promotes proliferation and migration of endothelial cells. Promotes blood vessel formation.

Why Choose Us?

Our expert technical team provides a one-stop, targeted, high-quality solution for studying the paracrine effects of animal MSCs.

BioVenic thoroughly and accurately characterizes secretome components by combining a high-throughput omics detection platform with multiplex immunoassay detection methods.

To ensure authenticity and bioinformatics analysis results, our standardized service process includes a quality inspection and identification process.

BioVenic has extensive experience in the field of animal stem cells. We have mastered multiple technologies to regulate paracrine effects and to analyze paracrine components in MSCs, which is perfectly suited to the diverse project requirements of scientific researchers. The promotion of tissue repair and regeneration by paracrine cytokines is a highly complex process involving multiple factors. We are committed to thoroughly exploring the biological functions facilitated by the paracrine effects of MSCs and their unlimited potential in the veterinary field as well as in the advancement of non-cellular therapy research. If you are interested in paracrine function or expression analysis of animal MSCs, please don't hesitate to contact us to discuss your research plan.

References

Image retrieved from Figure 2 "EV-mediated paracrine action of MSCs in angiogenesis." Maacha et al., 2020, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "MSCs Promote New Blood Vessel Formation in A Paracrine Manner."
Maacha, Selma, et al. "Paracrine mechanisms of mesenchymal stromal cells in angiogenesis." Stem cells international 2020 (2020).