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Recombinant Canine Thrombomodulin (THBD), N-His-GST
Product Overview
BioVenic's Recombinant Canine Thrombomodulin (THBD), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 53.5 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Canine thrombomodulin (TM) is a membrane glycoprotein expressed on endothelial cells, playing a major role in the protein C anticoagulation pathway. It helps to regulate blood coagulation by binding to thrombin, which in turn inhibits thrombin's procoagulant activities and promotes the activation of protein C, an anticoagulant. TM also has anti-inflammatory properties and is involved in the modulation of inflammation and coagulation in sepsis. In dogs, TM expression can be down-regulated in the presence of inflammation, which can lead to an increased risk of thrombosis and disseminated intravascular coagulation.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.