Mouse Anti-Canine Ephrin A2 Monoclonal Antibody

Canine ephrin A2 is a protein that plays a significant role in the development of the nervous system, particularly in the differentiation of excitatory neurons and the migration of interneurons in the neocortex. The loss of ephrin-A2 during development can lead to disruptions in the establishment of neocortical layers, resulting in patches depleted of neurons. This suggests that ephrin-A2 is crucial for the normal production and migration of neurons before they reach the cortical plate. Additionally, ephrin-A2 contributes to the establishment of neocortical interneurons, indicating its importance in the development and architecture of the neocortex. These functions of Ephrin A2 in dogs underscore its potential as a target for therapeutic interventions in neurological conditions and diseases associated with abnormal neural development.