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Mouse Anti-Porcine Beta-Secretase (BACE) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for porcine beta-secretase. It can be applied to WB assay of porcine beta-secretase.
Specifications
Target Information
Beta-secretase (BACE) is a transmembrane aspartyl protease that plays a pivotal role in the amyloid pathway of Alzheimer's disease. It catalyzes the first step in the cleavage of amyloid precursor protein (APP) to generate amyloid-beta peptides, which aggregate to form amyloid plaques in the brains of Alzheimer's patients. BACE's activity is tightly regulated and its upregulation has been linked to increased amyloid-beta production. Inhibition of BACE has been a major focus in the development of Alzheimer's therapies due to its critical role in amyloid-beta generation.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Chacón-Quintero, María Victoria, et al. "Beta-secretase 1 underlies reactive astrocytes and endothelial disruption in neurodegeneration." Frontiers in cellular neuroscience 15 (2021): 656832.