Mouse Anti-Porcine Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Monoclonal Antibody

Porcine ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), also known as Autotaxin (ATX), is a membrane-bound enzyme that plays a significant role in the conversion of lysophosphatidyl choline (LPC) to lysophosphatidic acid (LPA). This conversion is crucial for various biological processes, including cell proliferation, migration, and survival. ENPP2 is part of the ENPP family, which is involved in key biological and pathophysiological processes such as nucleotide and phospholipid signaling, bone mineralization, fibrotic diseases, and tumor-associated immune cell infiltration. In pigs, ENPP2 has been implicated in skeletal myogenesis, where it is regulated by the WNT/β-Catenin signaling pathway. ENPP2 function is essential for myogenic differentiation, and its activity is required for proper muscle regeneration after injury. Mice lacking the ENPP2 gene show disrupted muscle regeneration, emphasizing the importance of ENPP2 in muscle development and repair.