Mouse Anti-Porcine F-Box Protein 32 (FBXO32) Monoclonal Antibody

Porcine F-box protein 32 (FBXO32), also known as atrogin-1, is a component of the ubiquitin protein ligase complex, specifically part of the SCF (SKP1-cullin-F-box) family of E3 ubiquitin ligases. This protein plays a crucial role in the regulation of protein degradation, particularly during muscle atrophy, and has been identified as a potential drug target for the treatment of muscle wasting conditions. FBXO32 is highly expressed in tissues such as the endometrium and heart, and its expression can have significant implications for muscle mass development. Intriguingly, the protein is also implicated in the regulation of the cell cycle and transformation, highlighting its potential role in cellular processes beyond muscle metabolism. Furthermore, FBXO32 has been shown to be involved in the regulation of cell survival through the TGF-beta/Smad4 signaling pathway, suggesting its potential as a biomarker for colorectal carcinoma and a factor in disease progression. The diverse functions of FBXO32 underscore the importance of F-box proteins in maintaining cellular homeostasis and their potential as therapeutic targets in various diseases.