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Rabbit Anti-Porcine Insulin Receptor Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for porcine insulin receptor. It is purified by affinity chromatography. It can be applied to IHC, IF, WB and ELISA assays of porcine insulin receptor.
Specifications
Target Information
Porcine Insulin Receptor (INSR) is a key receptor involved in mediating the biological effects of insulin, which regulates glucose uptake and metabolism. The receptor is a transmembrane glycoprotein that, upon binding to insulin, activates downstream signaling pathways such as the PI3K/Akt pathway, promoting glucose uptake and utilization. INSR is highly expressed in tissues like liver, muscle, and adipose tissue, where it plays a crucial role in maintaining glucose homeostasis. Dysregulation of INSR signaling is associated with insulin resistance and type 2 diabetes.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Zick, Y., et al. "The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor." Journal of Biological Chemistry 259.7 (1984): 4396-4400.