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Recombinant Chicken Insulin-Like Growth Factor-Binding Protein 4 (IGFBP4), N-His
Product Overview
BioVenic's Recombinant Chicken Insulin-Like Growth Factor-Binding Protein 4 (IGFBP4), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 29.7 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Chicken insulin-like growth factor-binding protein 4 (IGFBP4) is a member of the IGFBP family, which plays a role in the systemic and local regulation of IGF activity. It binds to insulin-like growth factors (IGFs) I and II, and is involved in the regulation of various processes including cell growth, differentiation, and apoptosis [337^]. In chickens, IGFBP4 has been shown to have an important regulatory role in the differentiation of granulosa cells within the ovary, which is crucial for follicle development and egg production [325^][326^]. Overexpression of IGFBP4 can inhibit apoptosis and promote autophagy in these cells, suggesting its role in intracellular cholesterol and lipid droplet accumulation, which are important for steroidogenesis.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.